ponatinib hydrochloride and its Impurities

A multi-targeted tyrosine-kinase inhibitor, Ponatinib Hydrochloride is used in treating chronic myeloid leukemia. Shows antiangiogenic and antineoplastic activities.Reference standards of Ponatinib Hydrochloride API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.