Osimertinib is used to treat locally advanced or metastatic non-small-cell lung cancer. It is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor.Reference standards of Osimertinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Osimertinib
Catalogue No.:PA 15 51000
CAS :
Molecular Formula : C28H33N7O2
Molecular Weight : 499.61
3,3'-(Pyrimidine-2,4-diyl)bis(1-methyl-1H-indole)
Catalogue No.:PA 15 51510
Molecular Formula : C22H18N4
Molecular Weight : 338.41
3-(4-Chloropyrimidin-2-yl)-1-methyl-1H-indole
Catalogue No.:PA 15 51520
Molecular Formula : C13H10ClN3
Molecular Weight : 243.69
4-Fluoro-2-methoxy-3-nitroaniline
Catalogue No.:PA 15 51530
Molecular Formula : C7H7FN2O3
Molecular Weight : 186.14
2,4-Difluoronitrobenzene
Catalogue No.:PA 15 51540
Molecular Formula : C6H3F2NO2
Molecular Weight : 159.09
2-Dimethylaminoethanol
Catalogue No.:PA 15 51550
Molecular Formula : C4H11NO
Molecular Weight : 89.14
2-(tert-Butoxy)-4-fluoro-5-nitroaniline
Catalogue No.:PA 15 51560
Molecular Formula : C10H13FN2O3
Molecular Weight : 228.22
4-Fluoro-6-methoxy-2,3-dinitroaniline
Catalogue No.:PA 15 51570
Molecular Formula : C7H6FN3O5
Molecular Weight : 231.14
Osimertinib-d6
Catalogue No.:PA STI 070432
Molecular Formula : C28H27D6N7O2
Molecular Weight : 505.66
Osimertinib-13CD3
Catalogue No.:PA STI 070433
Molecular Formula : C2713CH30D3N7O2
Molecular Weight : 503.63
Osimertinib N,N'-Dioxide
Catalogue No.:PA 15 51580
Molecular Formula : C28H33N7O4
Molecular Weight : 531.62
N-Acryloyl Osimertinib
Catalogue No.:PA 15 51590
Molecular Formula : C31H35N7O3
Molecular Weight : 553.65
Osimertinib N-Oxide
Catalogue No.:PA 15 0511000
Molecular Formula : C28H33N7O3
Molecular Weight : 515.62
N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)propanamide
Catalogue No.:PA 15 0511001
Molecular Formula : C53H64N14O3
Molecular Weight : 945.19
N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-N-(3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-3-oxopropyl)acrylamide
Catalogue No.:PA 15 0511002
Molecular Formula : C56H66N14O4
Molecular Weight : 999.24
N-(2-((2-Acrylamido-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)(methyl)amino)ethyl)-3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-N,N-dimethyl-3-oxopropan-1-aminium Chloride
Catalogue No.:PA 15 0511003
Molecular Formula : C56H67ClN14O4
Molecular Weight : 1035.7
N-(5-((4-(1H-Indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide
Catalogue No.:PA 15 0511004
Molecular Formula : C27H31N7O2
Molecular Weight : 485.59
5-Methoxy-N1,N1-dimethyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine hydrochloride
Catalogue No.:PA 15 0511005
Molecular Formula : C22H25ClN6O
Molecular Weight : 424.93
2-Methoxy-N4,N4-dimethyl-N1-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-5-nitrobenzene-1,4-diamine
Catalogue No.:PA 15 0511006
Molecular Formula : C22H22N6O3
Molecular Weight : 418.46
N-(4-Methoxy-2-(methyl(2-(methylamino)ethyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
Catalogue No.:PA 15 0511007
N4-(4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrimidin-2-yl)-5-methoxy-N1-methyl-N1-(2-(methyl(methyl-d3)amino)ethyl)benzene-1,2,4-triamine
Catalogue No.:PA STI 088985
Molecular Formula : C27H30D3N7O
Molecular Weight : 474.63
N-(5-((4-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(2-(methyl(methyl-d3)amino)ethyl)amino)phenyl)acrylamide
Catalogue No.:PA STI 088986
Molecular Formula : C30H32D3N7O2
Molecular Weight : 528.68
N-(2-(Dimethylamino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
Catalogue No.:PA 15 0511008
Molecular Formula : C25H26N6O2
Molecular Weight : 442.52
2-Amino-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenol
Catalogue No.:PA 15 0511009
Molecular Formula : C20H19N5O2
Molecular Weight : 361.41
N-(2-((2-acrylamido-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)(methyl)amino)ethyl)-3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-N,N-dimethyl-3-oxopropan-1-aminium
Catalogue No.:PA 15 0511010
Molecular Formula : C56H67N14O4
Molecular Weight : 1000.25
N-(5-((4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide hydrochloride
Catalogue No.:PA 15 0511011
Molecular Formula : C27H32ClN7O2
Molecular Weight : 522.05
2-((2-Acrylamido-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)(methyl)amino)-N,N-dimethyl-N-((2-oxopyrrolidin-1-yl)methyl)ethan-1-aminium chloride
Catalogue No.:PA 15 0511012
Molecular Formula : C33H41ClN8O3
Molecular Weight : 633.19
N4-(4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrimidin-2-yl)-N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methylbenzene-1,2,4-triamine
Catalogue No.:PA 15 0511013
Molecular Formula : C27H33N7O
Molecular Weight : 471.61
N-(5-((4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide
Catalogue No.:PA 15 0511015
Molecular Formula : C30H35N7O2
Molecular Weight : 525.66
2-((2-Acrylamido-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)(methyl)amino)-N,N-dimethylethan-1-amine oxide
Catalogue No.:PA 15 0511016
Osimertinib Acetyl Impurity
Catalogue No.:PA 15 0511017
Molecular Formula : C27H33N7O2
Molecular Weight : 487.61
Osimertinib 2-Amide Impurity
Catalogue No.:PA 15 0511018
Molecular Formula : C23H20FN5O2
Molecular Weight : 417.44
3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole
Catalogue No.:PA 15 0511020
4-Fluoro-2-methoxy-5-nitroaniline
Catalogue No.:PA 15 0511019
3-Chloro-N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)propanamide
Catalogue No.:PA 15 0511021
Molecular Formula : C28H34ClN7O2
Molecular Weight : 536.08
N1-(2-(Dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine
Catalogue No.:PA 15 0511022
Molecular Formula : C25H31N7O
Molecular Weight : 445.57
N1,N5-Bis(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-2-methylenepentanediamide
Catalogue No.:PA 15 0511023
Osimertinib Methoxy Impurity
Catalogue No.:PA 15 0511024
Molecular Formula : C29H37N7O3
Molecular Weight : 531.66
N-(2-Hydroxy-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
Catalogue No.:PA 15 0511025
Molecular Formula : C23H21N5O3
Molecular Weight : 415.45
Osimertinib Dimer 2
Catalogue No.:PA 15 0511026
Molecular Formula : C57H68N14O4
Molecular Weight : 1013.27
Osimertinib N-Methylacrylamide Impurity
Catalogue No.:PA 15 0511027
Molecular Formula : C30H33N7O3
Molecular Weight : 539.64
1-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)azetidin-2-one
Catalogue No.:PA 15 0511028
Molecular Weight : 499.62
N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
Catalogue No.:PAI 15 051001
3-((2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)propanoic acid
Catalogue No.:PAI 15 051002
Molecular Formula : C28H35N7O3
Molecular Weight : 517.63
N-(4-Fluoro-2-methoxyphenyl)acetamide
Catalogue No.:PA 15 0511029
Molecular Formula : C9H10FNO2
Molecular Weight : 183.18
1-Fluoro-5-methoxy-2,4-dinitrobenzene
Catalogue No.:PA 15 0511030
Molecular Formula : C7H5FN2O5
Molecular Weight : 216.12
N-(4-Fluoro-2-methoxy-5-nitrophenyl)acetamide
Catalogue No.:PA 15 0511031
Molecular Formula : C9H9FN2O4
Molecular Weight : 228.18
N-(4-Methoxy-2-(methyl(2-(methylamino)ethyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide Hydrochloride
Catalogue No.:PA 15 0511032
N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-nitroso-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
Catalogue No.:PA 15 0511033
Molecular Formula : C27H30N8O3
Molecular Weight : 514.59
N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)(nitroso)amino)phenyl)acrylamide
Catalogue No.:PA 15 0511034
Molecular Formula : C28H32N8O3
Molecular Weight : 528.62
N-(2-((2-(Dimethylamino)ethyl)(nitroso)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
Catalogue No.:PA 15 0511035
N-(4-Methoxy-2-(methyl(2-(methyl(nitroso)amino)ethyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
Catalogue No.:PA 15 0511036
2,2,2-Trifluoro-N-(4-fluoro-2-methoxy-5-nitrophenyl)acetamide
Catalogue No.:PA 15 0511037
Molecular Formula : C9H6F4N2O4
Molecular Weight : 282.15
O-Desmethyl Osimertinib Impurity
Catalogue No.:PA 15 0511038
Catalogue No.:PA 15 0511039
N-(2,4-Dimethoxyphenyl)acrylamide
Catalogue No.:PA 15 0511040
Molecular Formula : C11H13NO3
Molecular Weight : 207.23
N-(2-Methoxyphenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine
Catalogue No.:PA 15 0511041
Molecular Formula : C20H18N4O
Molecular Weight : 330.39
Ethyl (3R,4R,5S)-5-(allylamino)-4-(N-(tert-butyl)acetamido)-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate
Catalogue No.:PA 15 0511042
Molecular Formula : C23H40N2O4
Molecular Weight : 408.58
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