A Nintedanib is used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer. It is a small molecule kinase inhibitor. Reference standards of Nintedanib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Nintedanib
Catalogue No.:PA 14 54000
CAS :
Molecular Formula : C31H33N5O4
Molecular Weight : 539.62
Intedanib E-isomer
Catalogue No.:PA 14 54510
(Z)-3-(((4-(N-Methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylic Acid
Catalogue No.:PA 14 54520
Molecular Formula : C30H31N5O4
Molecular Weight : 525.6
(Z)-1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1,4-dioxide
Catalogue No.:PA 14 54530
Molecular Formula : C31H33N5O6
Molecular Weight : 571.62
(Z)-Methyl 3-((methyl(4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 54540
Molecular Formula : C32H35N5O4
Molecular Weight : 553.65
(Z)-Methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 54550
Molecular Formula : C24H21N3O3
Molecular Weight : 399.44
(Z)-Methyl 1-acetyl-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 54560
Molecular Formula : C33H35N5O5
Molecular Weight : 581.66
(Z)-Methyl 3-(((4-(N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 54570
Molecular Formula : C26H23N3O4
Molecular Weight : 441.48
(3Z,3'Z)-Dimethyl 3,3'-(((((2,2'-(piperazine-1,4-diyl)bis(acetyl))bis(methylazanediyl))bis(4,1-phenylene))bis(azanediyl))bis(phenylmethanylylidene))bis(2-oxoindoline-6-carboxylate)
Catalogue No.:PA 14 54580
Molecular Formula : C56H52N8O8
Molecular Weight : 965.06
Methyl (3Z)-3-[({4-[2-(4-ethylpiperazin-1-yl)-N-methylacetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
Catalogue No.:PA 14 54590
(Z)-1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1-oxide
Catalogue No.:PA 14 54600
Molecular Formula : C31H33N5O5
Molecular Weight : 555.62
Ethyl (3Z)-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
Catalogue No.:PA 14 54610
Nintedanib Esylate
Catalogue No.:PA 14 54620
Molecular Formula : C33H39N5O7S
Molecular Weight : 649.76
Methyl Ethanesulfonate
Catalogue No.:PA 14 54630
Molecular Formula : C3H8O3S
Molecular Weight : 124.16
Ethyl Ethanesulfonate
Catalogue No.:PA 14 54640
Molecular Formula : C4H10O3S
Molecular Weight : 138.19
Intedanib-d3
Catalogue No.:PA STI 053200
Molecular Formula : C31H30D3N5O4
Molecular Weight : 542.64
Methyl (Z)-3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 54650
Molecular Formula : C17H13NO4
Molecular Weight : 295.29
(3E)-1-Acetyl-3-(ethoxyphenylmethylene)-2,3-dihydro-2-oxo-1H-indole-6-carboxylic Acid Methyl Ester
Catalogue No.:PA 14 54660
Molecular Formula : C21H19NO5
Molecular Weight : 365.38
Methyl (Z)-3-(((4-hydroxyphenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 54670
Molecular Formula : C23H18N2O4
Molecular Weight : 386.41
N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
Catalogue No.:PA 14 54680
Molecular Formula : C14H22N4O
Molecular Weight : 262.36
Desmethyl Nintedanib Carboxylic Acid
Catalogue No.:PA 14 54690
Molecular Formula : C29H29N5O5
Molecular Weight : 527.58
Desmethyl 5-Methoxycarbonyl Nintedanib
Catalogue No.:PA 14 54700
Molecular Weight : 525.61
Desmethyl 7-Methoxycarbonyl Nintedanib
Catalogue No.:PA 14 54710
Methyl (E)-3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 54720
Molecular Weight : 399.45
Desmethoxycarbonyl Nintedanib
Catalogue No.:PA 14 54730
Molecular Formula : C29H31N5O2
Molecular Weight : 481.6
4-Methyl-1-piperazinyl-acetyl Nintedanib Amide
Catalogue No.:PA 14 54740
Molecular Formula : C44H51N9O4
Molecular Weight : 769.95
2,2'-(Piperazine-1,4-diyl)bis(N-(4-aminophenyl)-N-methylacetamide)
Catalogue No.:PA 14 0541000
Molecular Formula : C22H30N6O2
Molecular Weight : 410.52
(E)-Methyl 3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541001
Molecular Formula : C18H15NO4
Molecular Weight : 309.32
(E)-Methyl 1-acetyl-2-oxo-3-(phenyl(piperidin-1-yl)methylene)indoline-6-carboxylate
Catalogue No.:PA 14 0541002
Molecular Formula : C24H24N2O4
Molecular Weight : 404.47
Methyl (E)-2-oxo-3-(phenyl(piperidin-1-yl)methylene)indoline-6-carboxylate
Catalogue No.:PA 14 0541003
Molecular Formula : C22H22N2O3
Molecular Weight : 362.43
Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-7-carboxylate
Catalogue No.:PA 14 0541004
Molecular Weight : 539.64
Desmethyl Nintedanib
Catalogue No.:PA 14 0541005
Methyl (E)-1-acetyl-3-(((4-(2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541006
Molecular Formula : C32H33N5O5
Molecular Weight : 567.65
Methyl (E)-3-(((4-(N-methyl-2-(piperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541007
6-Carboxyoxindole
Catalogue No.:PA 14 0541008
Molecular Formula : C9H7NO3
Molecular Weight : 177.16
3-Benzoyl-2-oxoindoline-6-carboxylic Acid
Catalogue No.:PA 14 0541009
Molecular Formula : C16H11NO4
Molecular Weight : 281.27
Ethyl (E)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541010
Molecular Weight : 553.66
Methyl (Z)-1-acetyl-3-(ethoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541011
Molecular Formula : C28H36N4O2S
Molecular Weight : 365.39
Ethyl (Z)-3-(ethoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541012
Molecular Formula : C20H19NO4
Molecular Weight : 337.38
Methyl (E)-1-(2-chloroacetyl)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541013
Molecular Formula : C20H16ClNO5
Molecular Weight : 385.8
N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-(((2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)acetamide
Catalogue No.:PA 14 0541014
Dimethyl 2-oxoindoline-3,6-dicarboxylate
Catalogue No.:PA 14 0541015
Molecular Formula : C12H11NO5
Molecular Weight : 249.22
Methyl (Z)-1-(2-methoxy-2-oxoethyl)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541016
Molecular Formula : C34H37N5O6
Molecular Weight : 611.7
Isopropyl (Z)-1-(2-methoxy-2-oxoethyl)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541017
Molecular Formula : C36H41N5O6
Molecular Weight : 639.75
Dimethyl (E)-3-(ethoxy(phenyl)methylene)-2-oxoindoline-1,6-dicarboxylate
Catalogue No.:PA 14 0541018
Molecular Formula : C21H19NO6
Molecular Weight : 381.38
N-Methyl-N-(4-(methylamino)phenyl)-2-(4-methylpiperazin-1-yl)acetamide
Catalogue No.:PA 14 0541019
Molecular Formula : C15H24N4O
Molecular Weight : 276.38
(E)-3-(((4-(2-(4-Methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylic acid
Catalogue No.:PA 14 0541020
Molecular Formula : C29H29N5O4
Molecular Weight : 511.58
(2S,3S,4S,5R,6R)-4,5,6-Trihydroxy-2-((((Z)-6-(methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)(4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)tetrahydro-2H-pyran-3-carboxylic acid
Catalogue No.:PA 14 0541021
Molecular Formula : C37H41N5O10
Molecular Weight : 715.76
Methyl (Z)-1-acetyl-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541022
Molecular Formula : C20H17NO5
Molecular Weight : 351.36
Methyl (Z)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541023
(Z)-4-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-1-methylpiperazine 1-oxide
Catalogue No.:PA 14 0541024
Molecular Weight : 555.64
Dimethyl 2-(4-(methoxycarbonyl)-2-nitrophenyl)malonate
Catalogue No.:PA 14 0541027
Molecular Formula : C13H13NO8
Molecular Weight : 311.25
Methyl (E)-1-acetyl-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541026
Methyl 2-oxo-2H-indole-6-carboxylate
Catalogue No.:PA 14 0541025
Molecular Formula : C10H7NO3
Molecular Weight : 189.17
Nintedanib N-Acetyl Impurity
Catalogue No.:PA 14 0541028
Molecular Weight : 581.67
Nintedanib Demethyl-O-glucuronic Acid
Catalogue No.:PA 14 0541029
Molecular Formula : C36H39N5O10
Molecular Weight : 701.73
Methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541030
Methyl 3-benzoyl-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541031
N-(2-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
Catalogue No.:PA 14 0541032
Ethyl 2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541033
Molecular Formula : C11H11NO3
Molecular Weight : 205.21
Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)(nitroso)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541034
Molecular Formula : C31H32N6O5
Molecular Weight : 568.63
Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxo-1-propionylindoline-6-carboxylate
Catalogue No.:PA 14 0541035
Molecular Formula : C34H37N5O5
Molecular Weight : 595.7
Methyl 3-((dimethylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541036
Molecular Formula : C19H18N2O3
Molecular Weight : 322.36
Methyl 3-(ethoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541037
Molecular Formula : C19H17NO4
Molecular Weight : 323.35
Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-1-nitroso-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541038
N-nitroso-N-desmethylnintedanib
Catalogue No.:PA 14 0541039
Molecular Formula : C30H30N6O5
Molecular Weight : 554.61
Nintedanib Acetamide Impurity
Catalogue No.:PA 14 0541040
Molecular Formula : C13H20N4O
Molecular Weight : 248.33
Nintedanib 4-Nitrophenyl 2-(4-Nitroso)
Catalogue No.:PA 14 0541042
Molecular Formula : C13H17N5O4
Molecular Weight : 307.31
2,2'-(Piperazine-1,4-diyl)bis(N-methyl-N-(4-nitrophenyl)acetamide)
Catalogue No.:PA 14 0541041
Molecular Formula : C22H26N6O6
Molecular Weight : 470.49
Methyl 1-acetyl-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541043
Molecular Formula : C12H11NO4
Molecular Weight : 233.22
Dimethyl 3,3'-(((((2,2'-(piperazine-1,4-diyl)bis(acetyl))bis(methylazanediyl))bis(4,1-phenylene))bis(azanediyl))bis(phenylmethanylylidene))bis(1-acetyl-2-oxoindoline-6-carboxylate)
Catalogue No.:PA 14 0541044
Molecular Formula : C60H56N8O10
Molecular Weight : 1049.15
1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1,4-dioxide
Catalogue No.:PA 14 0541045
Molecular Weight : 571.63
N-(4-Aminophenyl)-2-chloro-N-methylacetamide
Catalogue No.:PA 14 0541046
Molecular Formula : C9H11ClN2O
Molecular Weight : 198.65
Methyl 4-chloro-3-nitrobenzoate
Catalogue No.:PA 14 0541047
Molecular Formula : C8H6ClNO4
Molecular Weight : 215.59
N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide
Catalogue No.:PA 14 0541048
Molecular Formula : C14H20N4O3
Molecular Weight : 292.34
Methyl 3-(((4-hydroxyphenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541049
Dimethyl 2-(2-amino-4-(methoxycarbonyl)phenyl)malonate
Catalogue No.:PA 14 0541050
Molecular Formula : C13H15NO6
Molecular Weight : 281.26
6-(Methoxycarbonyl)-2-oxoindoline-3-carboxylic Acid
Catalogue No.:PA 14 0541051
Molecular Formula : C11H9NO5
Molecular Weight : 235.2
2-(4-(Methoxycarbonyl)-2-nitrophenyl)acetic Acid
Catalogue No.:PA 14 0541052
Molecular Formula : C10H9NO6
Molecular Weight : 239.18
N-(4-Aminophenyl)-2,2-dichloro-N-methylacetamide
Catalogue No.:PA 14 0541053
Molecular Formula : C9H10Cl2N2O
Molecular Weight : 233.09
N-(4-Aminophenyl)-N-methyl-2,2-bis(4-methylpiperazin-1-yl)acetamide
Catalogue No.:PA 14 0541054
Molecular Formula : C19H32N6O
Molecular Weight : 360.51
N-(4-Aminophenyl)-2-(4-methylpiperazin-1-yl)-N-(2-(piperazin-1-yl)acetyl)acetamide
Catalogue No.:PA 14 0541055
Molecular Formula : C19H30N6O2
Molecular Weight : 374.49
N-(4-Aminophenyl)-2-((4-aminophenyl)(methyl)amino)acetamide
Catalogue No.:PA 14 0541056
Molecular Formula : C15H18N4O
Molecular Weight : 270.34
N-(4-Aminophenyl)-N-methyl-2-(piperazin-1-yl)acetamide
Catalogue No.:PA 14 0541057
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