lubiprostone and its Impurities
Lubiprostone used in the management of idiopathic chronic constipation. It is sold under the trade name Amitiza. Reference standards of Lubiprostone API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


7-((2S,4aS,5S,7aS)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoic Acid
7-((2S,4aS,5S,7aS)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoic Acid
Catalogue No.:PA 12 87510
CAS :
2743427-14-5
Molecular Formula : C20H32F2O5
Molecular Weight : 390.46


7-((1S,2R,5R,8S)-2-(1,1-Difluoropentyl)-2,8-dihydroxy-7-oxobicyclo[3.2.1]octan-6-yl)heptanoic Acid
7-((1S,2R,5R,8S)-2-(1,1-Difluoropentyl)-2,8-dihydroxy-7-oxobicyclo[3.2.1]octan-6-yl)heptanoic Acid
Catalogue No.:PA 12 87540
CAS :
NA
Molecular Formula : C20H32F2O5
Molecular Weight : 390.46


7-((2R,4aR,5S,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoic Acid
7-((2R,4aR,5S,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoic Acid
Catalogue No.:PA 12 0871002
CAS :
1263283-38-0
Molecular Formula : C20H32F2O5
Molecular Weight : 390.47


(3aR,4R,5R,6aS)-2-oxo-5-((Tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-4-carbaldehyde
(3aR,4R,5R,6aS)-2-oxo-5-((Tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-4-carbaldehyde
Catalogue No.:PA 12 0871005
CAS :
32233-41-3
Molecular Formula : C13H18O5
Molecular Weight : 254.28


(3AR,4S,5R,6aS)-4-(Hydroxymethyl)-5-((tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-2-one
(3AR,4S,5R,6aS)-4-(Hydroxymethyl)-5-((tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-2-one
Catalogue No.:PA 12 0871006
CAS :
69222-61-3
Molecular Formula : C13H20O5
Molecular Weight : 256.3


rel-(3aR,4S,5R,6aS)-5-Hydroxy-4-(hydroxymethyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one
rel-(3aR,4S,5R,6aS)-5-Hydroxy-4-(hydroxymethyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one
Catalogue No.:PA 12 0871009
CAS :
54423-47-1
Molecular Formula : C8H12O4
Molecular Weight : 172.18


7-((1R,2R,3R)-2-(4,4-difluoro-3-hydroxyoctyl-6,6,7,7,8,8,8-d7)-3-hydroxy-5-oxocyclopentyl)heptanoic acid
7-((1R,2R,3R)-2-(4,4-difluoro-3-hydroxyoctyl-6,6,7,7,8,8,8-d7)-3-hydroxy-5-oxocyclopentyl)heptanoic acid
Catalogue No.:PA STI 088979
CAS :
1217511-55-1
Molecular Formula : C20H27D7F2O5
Molecular Weight : 399.53


7-((1R,2R,3R)-2-(4,4-Difluoro-3-hydroxyoctyl)-3-hydroxy-5-oxocyclopentyl)heptanoic-3,3,4,4-d4 acid
7-((1R,2R,3R)-2-(4,4-Difluoro-3-hydroxyoctyl)-3-hydroxy-5-oxocyclopentyl)heptanoic-3,3,4,4-d4 acid
Catalogue No.:PA STI 088977
CAS :
NA
Molecular Formula : C20H30D4F2O5
Molecular Weight : 396.51


Cyclohexylmethyl 7-((2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoate
Cyclohexylmethyl 7-((2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoate
Catalogue No.:PA 12 0871012
CAS :
NA
Molecular Formula : C27H44F2O5
Molecular Weight : 486.64


Benzyl (Z)-7-((2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)hept-5-enoate
Benzyl (Z)-7-((2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)hept-5-enoate
Catalogue No.:PA 12 0871013
CAS :
1447733-80-3
Molecular Formula : C27H36F2O5
Molecular Weight : 478.58