Lonafarnib and its Impurities

Lonafarnib, sold under the brand name Zokinvy, is a medication used to reduce the risk of death due to Hutchinson-Gilford progeria syndrome and for the treatment of certain processing-deficient progeroid laminopathies. Reference standards of Lonafarnib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.