Ledipasvir is most commonly used in combination with sofosbuvir for treatment in chronic hepatitis C genotype 1 patients. Reference standards of Ledipasvir API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Ledipasvir
Catalogue No.:PA 12 77000
CAS :
Molecular Formula : C49H54F2N8O6
Molecular Weight : 889.00
tert-Butyl (1R,3R,4S)-3-(6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylate
Catalogue No.:PA 12 77510
Molecular Formula : C24H34BN3O4
Molecular Weight : 439.36
tert-Butyl (1S,3S,4R)-3-(6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylate
Catalogue No.:PA 12 77520
2-Amino-4'-bromoacetophenone Hydrochloride
Catalogue No.:PA 12 77530
Molecular Formula : C8H9BrClNO
Molecular Weight : 250.52
Ledipasvir-d6
Catalogue No.:PA STI 056231
Molecular Formula : C49H48D6F2N8O6
Molecular Weight : 895.04
Methyl ((S)-1-((S)-6-(5-(7-(2-((1R,3S,4S)-2-((methoxycarbonyl)-L-valyl)-2-azabicyclo[2.2.1]heptan-3-yl)-1H-benzo[d]imidazol-6-yl)-9-oxo-9H-fluoren-2-yl)-1H-imidazol-2-yl)-5-azaspiro[2.4]heptan-5-yl)-3-methyl-1-oxobutan-2-yl)carbamate
Catalogue No.:PA 12 77580
Molecular Formula : C49H54N8O7
Molecular Weight : 867.02
Methyl ((R)-1-((S)-6-(5-(9,9-difluoro-7-(2-((1R,3S,4S)-2-((methoxycarbonyl)-L-valyl)-2-azabicyclo[2.2.1]heptan-3-yl)-1H-benzo[d]imidazol-6-yl)-9H-fluoren-2-yl)-1H-imidazol-2-yl)-5-azaspiro[2.4]heptan-5-yl)-3-methyl-1-oxobutan-2-yl)carbamate
Catalogue No.:PA 12 0771000
Molecular Weight : 889
Methyl ((S)-1-((S)-6-(5-(9,9-difluoro-7-(2-((1R,3S,4S)-2-((methoxycarbonyl)-D-valyl)-2-azabicyclo[2.2.1]heptan-3-yl)-1H-benzo[d]imidazol-6-yl)-9H-fluoren-2-yl)-1H-imidazol-2-yl)-5-azaspiro[2.4]heptan-5-yl)-3-methyl-1-oxobutan-2-yl)carbamate
Catalogue No.:PA 12 0771001
Ledipasvir 1S,3R,4R-Diastereomer
Catalogue No.:PA 12 0771002
Ledipasvir 1S,3S,4R-Diastereomer
Catalogue No.:PA 12 0771003
(S)-5-(tert-Butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic Acid;
Catalogue No.:PA 12 0771004
Molecular Formula : C12H19NO4
Molecular Weight : 241.29
Ledipasvir D8
Catalogue No.:PA STI 089132
Molecular Formula : C49H46D8F2N8O6
Molecular Weight : 897.07
Ledipasvir Acetyl Spiro Impurity
Catalogue No.:PA 12 0771005
Molecular Formula : C44H45F2N7O4
Molecular Weight : 773.89
6-(7-(2-((S)-5-Azaspiro[2.4]heptan-6-yl)-1H-imidazol-5-yl)-9,9-difluoro-9H-fluoren-2-yl)-2-((1R,3S,4S)-2-azabicyclo[2.2.1]heptan-3-yl)-1H-benzo[d]imidazole Tetrahydrochloride
Catalogue No.:PA 12 0771007
Molecular Formula : C35H36Cl4F2N6
Molecular Weight : 720.51
Acetyl-L-threonine
Catalogue No.:PA 12 0771006
Molecular Formula : C6H11NO4
Molecular Weight : 161.16
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