Ivabradine is used for the symptomatic treatment of chronic stable angina pectoris in patients with normal sinus rhythm who cannot take beta blockers. It is marketed under the trade name Corlanor. Reference standards of Ivabradine API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Ivabradine
Catalogue No.:PA 09 58000
CAS :
Molecular Formula : C27H36N2O5
Molecular Weight : 468.59
Dehydro Ivabradine-d3
Catalogue No.:PA STI 025060
Molecular Formula : C27H31D3N2O5
Molecular Weight : 469.59
N-Demethyl Ivabradine-d6 Hydrochloride
Catalogue No.:PA STI 028660
Molecular Formula : C26H29D6ClN2O5
Molecular Weight : 497.06
Ivabradine-d3 Hydrochloride
Catalogue No.:PA STI 054520
Molecular Formula : C27H34D3ClN2O5
Molecular Weight : 508.06
Ivabradine-d6
Catalogue No.:PA STI 054521
Molecular Formula : C27H30D6N2O5
Molecular Weight : 474.62
3-(3-((((S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepine 3-Oxide
Catalogue No.:PA 09 0581000
Molecular Formula : C27H36N2O6
Molecular Weight : 484.59
(S)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepine-1,2(3H)-dione Oxalate
Catalogue No.:PA 09 0581001
Molecular Formula : C29H36N2O10
Molecular Weight : 572.61
[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]-carbamic acid ethyl ester
Catalogue No.:PA 09 0581002
Molecular Formula : C14H19NO4
Molecular Weight : 265.31
N-((3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)-N-methylacetamide
Catalogue No.:PA 09 0581003
Molecular Formula : C14H19NO3
Molecular Weight : 249.31
Ethyl (E)-N-((3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)formimidate
Catalogue No.:PA 09 0581004
3-(3-((((1R,3S,4R,6S,7S)-3,4-Dimethoxybicyclo[4.2.0]octan-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
Catalogue No.:PA 09 0581005
Molecular Formula : C27H42N2O5
Molecular Weight : 474.64
3-(3-((((1S,3R,4S,6R,7S)-3,4-Dimethoxybicyclo[4.2.0]octan-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
Catalogue No.:PA 09 0581006
3-(3-((((S)-3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-5-hydroxy-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
Catalogue No.:PA 09 0581007
3-(3-((3-Chloro-2-(3,4-dimethoxyphenyl)propyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
Catalogue No.:PA 09 0581008
Molecular Formula : C27H37ClN2O5
Molecular Weight : 505.05
3-Hydroxy Ivabradine
Catalogue No.:PA 09 0581009
Molecular Formula : C26H34N2O5
Molecular Weight : 454.57
7-(3-((((R)-3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-2,3-dimethoxy-5,7,8,9-tetrahydro-6H-benzo[7]annulen-6-one hydrochloride
Catalogue No.:PA 09 0241008
Molecular Formula : C28H38ClNO5
Molecular Weight : 504.06
3-(2,3-Dimethoxy-6-oxo-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl)-N-(((S)-3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)-N-methylpropan-1-amine oxide
Catalogue No.:PA 09 0581010
Molecular Formula : C28H37NO6
Molecular Weight : 483.61
3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride
Catalogue No.:PA 09 0581011
2-(3,4-Dimethoxyphenyl)-N-(2-oxoethyl)acetamide
Catalogue No.:PA 09 0581012
Molecular Formula : C12H15NO4
Molecular Weight : 237.26
4,5-Dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile
Catalogue No.:PA 09 0581013
Molecular Formula : C11H11NO2
Molecular Weight : 189.21
3-(3-Bromo-4,5-dimethoxyphenyl)propanenitrile
Catalogue No.:PA 09 0581014
Molecular Formula : C11H12BrNO2
Molecular Weight : 270.13
1-(((S)-3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)-3-(((S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)urea
Catalogue No.:PA 09 0581015
Molecular Formula : C23H28N2O5
Molecular Weight : 412.49
N-Nitroso N-Desmethyl DEBA
Catalogue No.:PA 09 0581016
Molecular Formula : C9H20N2O3
Molecular Weight : 204.27
N-Nitroso N-Desmethyl Ivabradine
Catalogue No.:PA 09 0581017
Molecular Formula : C26H33N3O6
Molecular Weight : 483.57
(S)-N-((3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)-N-methylacetamide
Catalogue No.:PA 09 0581018
(R)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
Catalogue No.:PA 09 0581019
3-(3-((((S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxydecahydro-2H-benzo[d]azepin-2-one Hydrochloride
Catalogue No.:PA 09 0581020
Molecular Formula : C27H43ClN2O5
Molecular Weight : 511.1
(S)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,5-dihydro-2H-benzo[d]azepine-2,4(3H)-dione
Catalogue No.:PA 09 0581021
Molecular Formula : C27H34N2O6
Molecular Weight : 482.58
(S)-3-Chloro-N-((3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)-N-methylpropan-1-amine
Catalogue No.:PA 09 0581022
Molecular Formula : C15H22ClNO2
Molecular Weight : 283.8
3-(3-Bromopropyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
Catalogue No.:PA 09 0581023
Molecular Formula : C15H20BrNO3
Molecular Weight : 342.23
3-(3-((((S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-1-hydroxy-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
Catalogue No.:PA 09 0581025
3-(3-(((4-Hydroxy-3-methoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
Catalogue No.:PA 09 0581024
(S)-3-(3-(((4-Hydroxy-3-methoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
Catalogue No.:PA 09 0581026
Ivabradine Dimer Impurity
Catalogue No.:PA 09 0581027
Molecular Formula : C41H53N3O8
Molecular Weight : 715.89
(S)-N-((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)-N-methylnitrous Amide
Catalogue No.:PA 09 0581028
Molecular Formula : C12H16N2O3
Molecular Weight : 236.27
(S)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-5-hydroxy-7,8-dimethoxy-1,3-dihydro-2H-benzo[d]azepin-2-one
Catalogue No.:PA 09 0581029
7,8-Dimethoxy-3-nitroso-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
Catalogue No.:PA 09 0581030
Molecular Formula : C12H14N2O4
Molecular Weight : 250.25
8-Demethyl Ivabradine Hydrochloride
Catalogue No.:PA 09 0581031
Molecular Formula : C26H35ClN2O5
Molecular Weight : 491.03
(R)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-2,3-dihydro-1H-benzo[d]azepine-1,4(5H)-dione
Catalogue No.:PA 09 0581032
7-Demethyl Ivabradine Hydrochloride
Catalogue No.:PA 09 0581033
(S)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-bis(methoxy-d3)-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one Hydrochloride
Catalogue No.:PA STI 089846
Molecular Formula : C27H31D6ClN2O5
Molecular Weight : 511.09
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