Isavuconazonium is used to treat invasive aspergillosis and invasive mucormycosis in adults ages 18 years and older. It is under the brand name Cresemba. It is a prodrug of isavuconazole. Reference standards of Isavuconazole API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Isavuconazole
Catalogue No.:PA 09 42000
CAS :
Molecular Formula : C22H17F2N5OS
Molecular Weight : 437.47
Isavuconazonium Sulfate
Catalogue No.:PA 09 42510
Molecular Formula : C35H36F2N8O9S2
Molecular Weight : 814.84
Isavuconazole-d4
Catalogue No.:PA STI 053620
Molecular Formula : C22H13D4F2N5OS
Molecular Weight : 441.49
(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide
Catalogue No.:PA 09 0421000
Molecular Formula : C13H14F2N4OS
Molecular Weight : 312.34
1-((2R,3S)-3-(4-(4-Cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-(1-((methyl(3-(((methylglycyl)oxy)methyl)pyridin-2-yl)carbamoyl)oxy)ethyl)-1H-1,2,4-triazol-4-ium Iodide Hydrochloride
Catalogue No.:PA 09 0421001
Molecular Formula : C35H36ClF2IN8O5S
Molecular Weight : 881.14
4-(1-(((3-(((N-(Tert-butoxycarbonyl)-N-methylglycyl)oxy)methyl)pyridin-2-yl)(methyl)carbamoyl)oxy)ethyl)-1-((2R,3S)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-1H-1,2,4-triazol-4-ium Iodide;
Catalogue No.:PA 09 0421002
Molecular Formula : C40H43F2IN8O7S
Molecular Weight : 944.79
(2R,3S)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanenitrile
Catalogue No.:PA 09 0421003
Molecular Formula : C13H12F2N4O
Molecular Weight : 278.26
(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanenitrile
Catalogue No.:PA 09 0421004
(2S,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide
Catalogue No.:PA 09 0421005
(2R,3S)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide
Catalogue No.:PA 09 0421006
(2S,3S)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide
Catalogue No.:PA 09 0421007
1-((2S,3R)-3-(4-(4-Cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-(1-((methyl(3-(((methylglycyl)oxy)methyl)pyridin-2-yl)carbamoyl)oxy)ethyl)-1H-1,2,4-triazol-4-ium Chloride Dihydrochloride
Catalogue No.:PA 09 0421008
Molecular Formula : C35H37Cl3F2N8O5S
Molecular Weight : 826.14
1-((2S,3S)-3-(4-(4-Cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-(1-((methyl(3-(((methylglycyl)oxy)methyl)pyridin-2-yl)carbamoyl)oxy)ethyl)-1H-1,2,4-triazol-4-ium Chloride Dihydrochloride
Catalogue No.:PA 09 0421009
1-((2R,3R)-3-(4-(4-Cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-(1-(((3-(hydroxymethyl)pyridin-2-yl)(methyl)carbamoyl)oxy)ethyl)-1H-1,2,4-triazol-4-ium Chloride
Catalogue No.:PA 09 0421010
Molecular Formula : C32H30ClF2N7O4S
Molecular Weight : 682.14
1-((2R,3R)-3-(4-(4-Cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-(1-(((3-(5,8-dimethyl-2-(3-(((methylglycyl)oxy)methyl)pyridin-2-yl)-3,7,10-trioxo-4,6,11-trioxa-2,8-diazadodecan-12-yl)pyridin-2-yl)(methyl)carbamoyl)oxy)ethyl)-1H-1,2,4-triazol-4-ium Chloride
Catalogue No.:PA 09 0421011
Molecular Formula : C49H52ClF2N11O11S
Molecular Weight : 1076.53
4-(2-((2S,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)thiazol-4-yl)benzonitrile
Catalogue No.:PA 09 0421012
rel-4-(2-((2R,3S)-3-(2,5-Difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)thiazol-4-yl)benzonitrile
Catalogue No.:PA 09 0421013
(S,S)-Isavuconazole
Catalogue No.:PA 09 0421014
4-(1-(((3-(((N-(tert-Butoxycarbonyl)-N-methylglycyl)oxy)methyl)pyridin-2-yl)(methyl)carbamoyl)oxy)ethyl)-1-((2R,3R)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-1H-1,2,4-triazol-4-ium Iodide
Catalogue No.:PA 09 0421015
1-((2R,3R)-3-(4-(4-Cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-(1-(((3-(hydroxymethyl)pyridin-2-yl)(methyl)carbamoyl)oxy)ethyl)-1H-1,2,4-triazol-4-ium Chloride Hydrochloride
Catalogue No.:PA 09 0421016
Molecular Formula : C32H31Cl2F2N7O4S
Molecular Weight : 718.6
(2-(Methylamino)pyridin-3-yl)methyl methylglycinate
Catalogue No.:PA 09 0421017
Molecular Formula : C10H15N3O2
Molecular Weight : 209.25
Isavuconazole Methyl Ester Impurity
Catalogue No.:PA 09 0421018
Molecular Formula : C36H39F2N7O11S2
Molecular Weight : 847.86
4-(1-(((3-(((N-(tert-Butoxycarbonyl)-N-methylglycyl)oxy)methyl)pyridin-2-yl)(methyl)carbamoyl)oxy)ethyl)-1-((2R,3R)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-1H-1,2,4-triazol-4-ium Chloride
Catalogue No.:PA 09 0421019
Molecular Formula : C40H43ClF2N8O7S
Molecular Weight : 853.34
1-((2R,3R)-3-(4-(4-(tert-Butylcarbamoyl)phenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-(1-((methyl(3-(((methylglycyl)oxy)methyl)pyridin-2-yl)carbamoyl)oxy)ethyl)-1H-1,2,4-triazol-4-ium Chloride
Catalogue No.:PA 09 0421020
Molecular Formula : C39H45ClF2N8O6S
Molecular Weight : 827.35
4-(1-(((3-(((N-(tert-Butoxycarbonyl)-N-methylglycyl)oxy)methyl)pyridin-2-yl)(methyl)carbamoyl)oxy)ethyl)-1-((2R,3R)-2-(1-(((3-(((N-carboxy-N-methylglycyl)oxy)methyl)pyridin-2-yl)(methyl)carbamoyl)oxy)ethoxy)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)butyl)-1H-1,2,4-triazol-4-ium Chloride
Catalogue No.:PA 09 0421021
Molecular Formula : C54H60ClF2N11O13S
Molecular Weight : 1176.64
1-((2R,3R)-3-(4-(4-Cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-(1-((methyl(3-(((N-methyl-N-nitrosoglycyl)oxy)methyl)pyridin-2-yl)carbamoyl)oxy)ethyl)-1H-1,2,4-triazol-4-ium Hydrogen Sulfate
Catalogue No.:PA 09 0421022
Molecular Formula : C35H35F2N9O10S2
Molecular Weight : 843.83
1-(3-(4-(4-Cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-(1-(((3-(5,8-dimethyl-2-(3-(((methylglycyl)oxy)methyl)pyridin-2-yl)-3,7,10-trioxo-4,6,11-trioxa-2,8-diazadodecan-12-yl)pyridin-2-yl)(methyl)carbamoyl)oxy)ethyl)-1H-1,2,4-triazol-4-ium Hydrogen Sulfate
Catalogue No.:PA 09 0421023
Molecular Formula : C49H53F2N11O15S2
Molecular Weight : 1138.14
(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanoic Acid
Catalogue No.:PA 09 0421024
Molecular Formula : C13H13F2N3O3
Molecular Weight : 297.26
(2S,3S)-3-Amino-2-(2,5-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
Catalogue No.:PA 09 0421025
Molecular Formula : C12H14F2N4O
Molecular Weight : 268.27
(2R,3R)-2-(2,5-Difluorophenyl)-3-((tetrahydro-2H-pyran-2-yl)oxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
Catalogue No.:PA 09 0421026
Molecular Formula : C17H21F2N3O3
Molecular Weight : 353.37
(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(4H-1,2,4-triazol-4-yl)butanethioamide
Catalogue No.:PA 09 0421027
Mixture of Isavuconazonium Sulfate (2R,3S) and Isavuconazonium Sulfate (2S,3R)
Catalogue No.:PA 09 0421028
1-((2R,3R)-3-(4-(4-Cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-(1-(((3-(hydroxymethyl)pyridin-2-yl)(methyl)carbamoyl)oxy)ethyl)-4H-1,2,4-triazol-1-ium Hydrogen Sulfate
Catalogue No.:PA 09 0421029
Molecular Formula : C32H31F2N7O8S2
Molecular Weight : 743.76
1-((2S,3S)-3-(4-(4-Cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-(1-((methyl(3-(((methylglycyl)oxy)methyl)pyridin-2-yl)carbamoyl)oxy)ethyl)-1H-1,2,4-triazol-4-ium Hydrogen Sulfate
Catalogue No.:PA 09 0421030
4-(1-(((3-(((N-(tert-Butoxycarbonyl)-N-methylglycyl)oxy)methyl)pyridin-2-yl)(methyl)carbamoyl)oxy)ethyl)-1-((2R,3R)-2-(1-(((3-(((N-carboxy-N-methylglycyl)oxy)methyl)pyridin-2-yl)(methyl)carbamoyl)oxy)ethoxy)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)butyl)-1H-1,2,4-triazol-4-ium Hydrogen Sulfate
Catalogue No.:PA 09 0421031
Molecular Formula : C54H61F2N11O17S2
Molecular Weight : 1238.26
(2-(Methyl((vinyloxy)carbonyl)amino)pyridin-3-yl)methyl methylglycinate
Catalogue No.:PA 09 0421032
Molecular Formula : C13H17N3O4
Molecular Weight : 279.30
1-((2S,3R)-3-(4-(4-Cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-(1-((methyl(3-(((N-methyl-N-(methyl(3-(((methylglycyl)oxy)methyl)pyridin-2-yl)carbamoyl)glycyl)oxy)methyl)pyridin-2-yl)carbamoyl)oxy)ethyl)-1H-1,2,4-triazol-4-ium Hydrogen Sulfate
Catalogue No.:PA 09 0421033
Molecular Formula : C46H49F2N11O12S2
Molecular Weight : 1050.08
2-(Methyl((vinyloxy)carbonyl)amino)benzyl methylglycinate Hydrochloride
Catalogue No.:PA 09 0421034
Molecular Formula : C14H19ClN2O4
Molecular Weight : 314.77
1-((2S,3R)-3-(4-(4-Cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-(1-((methyl(3-(((methylglycyl)oxy)methyl)pyridin-2-yl)carbamoyl)oxy)ethyl)-1H-1,2,4-triazol-4-ium Chloride Hydrochloride
Catalogue No.:PA 09 0421035
Molecular Formula : C35H36Cl2F2N8O5S
Molecular Weight : 789.68
1-((2S,3S)-3-(4-(4-Cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-(1-((methyl(3-(((methylglycyl)oxy)methyl)pyridin-2-yl)carbamoyl)oxy)ethyl)-1H-1,2,4-triazol-4-ium Chloride Hydrochloride
Catalogue No.:PA 09 0421036
(2R)-1-(2,5-Difluorophenyl)-2-((tetrahydro-2H-pyran-2-yl)oxy)propan-1-one
Catalogue No.:PA 09 0421037
Molecular Formula : C14H16F2O3
Molecular Weight : 270.28
2-((1R)-1-(2-(2,5-Difluorophenyl)oxiran-2-yl)ethoxy)tetrahydro-2H-pyran
Catalogue No.:PA 09 0421038
Molecular Formula : C15H18F2O3
Molecular Weight : 284.3
1-((2-(2,4-Difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole
Catalogue No.:PA 09 0421039
Molecular Formula : C12H11F2N3O
Molecular Weight : 251.24
N-Benzylethanimine
Catalogue No.:PA 09 0421040
Molecular Formula : C9H11N
Molecular Weight : 133.19
(2-(Methylamino)pyridin-3-yl)methyl methylglycinate Dihydrochloride
Catalogue No.:PA 09 0421041
Molecular Formula : C10H17Cl2N3O2
Molecular Weight : 282.17
1-((2R,3R)-3-(4-(4-Carbamoylphenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-(1-((methyl(3-(((methylglycyl)oxy)methyl)pyridin-2-yl)carbamoyl)oxy)ethyl)-1H-1,2,4-triazol-4-ium Bromide Dihydrobromide
Catalogue No.:PA 09 0421042
Molecular Formula : C35H39Br3F2N8O6S
Molecular Weight : 977.52
4-(1-(((3-(((N-(tert-Butoxycarbonyl)-N-methylglycyl)oxy)methyl)pyridin-2-yl)(methyl)carbamoyl)oxy)ethyl)-1-((2R,3R)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-1H-1,2,4-triazol-4-ium 2,2,2-trifluoroacetate
Catalogue No.:PA 09 0421043
Molecular Formula : C42H43F5N8O9S
Molecular Weight : 930.91
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