Ingenol Mebutate and its Impurities

Ingenol Mebutate is used to treat actinic keratosis. It is a substance that is found in the sap of the plant Euphorbia peplus, commonly known as milkweed, and is an inducer of cell death. Reference standards of Ingenol Mebutate API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.