fialuridine and its Impurities

Fialuridine is a nucleoside analog that was developed to treat hepatitis B virus infection. In a clinical trial, fulminant liver failure developed after about a month, which was fatal for several patients and required liver transplantation for others. Reference standards of Fialuridine API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.