Everolimus is currently used as an immunosuppressant to prevent rejection of organ transplants. It is a derivative of Rapamycin, and works similarly to Rapamycin as an mTOR inhibitor. Reference standards of Everolimus API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
Everolimus
Catalogue No.:PA 05 73000
CAS :
Molecular Formula : C53H83NO14
Molecular Weight : 958.22
Everolimus O-Ethyl Impurity
Catalogue No.:PA 05 73650
Molecular Formula : C54H85NO14
Molecular Weight : 972.25
42-O-Formyl Rapamycin
Catalogue No.:PA 05 73670
Molecular Formula : C52H79NO14
Molecular Weight : 942.18
Everolimus Cyclic Hemiacetal
Catalogue No.:PA 05 73060
Molecular Formula : C55H89NO16
Molecular Weight : 1020.31
Formyl Sirolimus
Catalogue No.:PA 05 0730050
Molecular Weight : 942.2
Everolimus Isomer C
Catalogue No.:PA 05 73510
42-O-tert-Butyldimethylsilyloxyethyl Rapamycin
Catalogue No.:PA 05 73520
Molecular Formula : C59H97NO14Si
Molecular Weight : 1072.49
2-((tert-Butyldimethylsilyl)oxy)ethyl 2,2,2-trichloroacetimidate
Catalogue No.:PA 05 73530
Molecular Formula : C10H20Cl3NO2Si
Molecular Weight : 320.72
Desmethyl Everolimus
Catalogue No.:PA 05 73540
Molecular Formula : C52H81NO14
Molecular Weight : 944.2
(2S)-1-[[(2R,3R,6S)-6-[(2S,3E,5E,7E,9S,11R)-2,13-Dimethoxy-3,9,11-trimethyl-12-oxo-3,5,7-tridecatrienyl]tetrahydro-2-hydroxy-3-methyl-2H-pyran-2-yl]oxoacetyl]-2-piperidinecarboxylic Acid
Catalogue No.:PA 05 73550
Molecular Formula : C32H49NO9
Molecular Weight : 591.73
Seco Everolimus B
Catalogue No.:PA 05 73560
Molecular Formula : C53H85NO15
Molecular Weight : 976.24
1-(2-((2R,3R,6S)-2-Hydroxy-6-((2S,3E,5E,7E,9S,11R,14R,15E,17R,19E,21R)-14-hydroxy-22-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxodocosa-3,5,7,15,19-pentaen-1-yl)-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylic Acid
Catalogue No.:PA 05 73570
(S)-(2R,3S,6R,E)-1-((1S,3R,4R)-4-(2-Hydroxyethoxy)-3-methoxycyclohexyl)-2,6,8-trimethyl-5,9-dioxonon-7-en-3-yl 1-(2-((2R,3R,6S)-6-((2S,3E,5E,7E,9S,11R)-2,13-dimethoxy-3,9,11-trimethyl-12-oxotrideca-3,5,7-trien-1-yl)-2-hydroxy-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylate
Catalogue No.:PA 05 73580
1-(2-((2R,6S)-2-Hydroxy-6-((2R,3E,5E,7E,9R,11S,14R,15E,17S,19E,22R)-14-hydroxy-22-((1S,3R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxotricosa-3,5,7,15,19-pentaen-1-yl)tetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylic Acid
Catalogue No.:PA 05 73590
Everolimus 28-Ethylhydroxy Impurity
Catalogue No.:PA 05 73600
Catalogue No.:PA 05 73620
(1R,9S,12S,15S,16E,18R,19R,21R,23S,24Z,26E,28E,30S,35R)-1-18-Dihydroxy-12{(1R)-2-[1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-1-methylethyl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04.9]-hexatriaconta-16,24,26,28,-tetraene-2,3,10,14,20-pentanone
Catalogue No.:PA 05 73630
(1R,9S,12S,15S,16E,18R,19R,21R,23S,24E,26E,28E,30S,35R)-1-Hydroxy-12{(1R)-2-[1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-1-methylethyl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04.9]-hexatriaconta-16,24,26,28,-tetraene-2,3,10,14,18,20-Hexanone
Catalogue No.:PA 05 73640
Molecular Formula : C53H81NO14
Molecular Weight : 956.21
(2S)-1-[[(2R,3R,6S)-2-Hydroxy-6-[(2S,3E,5E,7E,9S,11R,13R,14R,15E,17R,19E,21R)-14- hydroxy-22-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-2,13-dimethoxy-3,9, 11,15,17,21-hexamethyl-12,18-dioxodocosa-3,5,7,15,19-pentaen-1-yl]-3-methyloxan-2- yl](oxo)acetyl]piperidine-2-carboxylic Acid
Catalogue No.:PA 05 73660
Everolimus 27-O-Desmethyl
Catalogue No.:PA 05 73680
Everolimus-d4
Catalogue No.:PA STI 040450
Molecular Formula : C53H79D4NO14
Molecular Weight : 962.25
Everolimus-13C2,D4
Catalogue No.:PA STI 040451
Molecular Formula : C5113C2H79D4NO14
Molecular Weight : 964.23
(2S)-1-[[(2R,3R,6S)-2-Hydroxy-6-[(2S,3E,5E,7E,9S,11R,13R,14R,15E,17R,19Z,21R)-14-hydroxy-22-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxodocosa-3,5,7,15,19-pentaen-1-yl]-3-methyltetrahydro-2H-pyran-2-yl](oxo)acetyl]piperidine-2-carboxylic Acid
Catalogue No.:PA 05 73020
Molecular Weight : 958.24
19-O-Demethyl Everolimus
Catalogue No.:PA 05 73030
Molecular Weight : 944.21
18-O-Hydroxyethyl sirolimus
Catalogue No.:PA 05 73040
2,6-di-tert-Butyl-4-methylenecyclohexa-2,5-dien-1-one
Catalogue No.:PA 05 0731000
Molecular Formula : C15H22O
Molecular Weight : 218.34
Everolimus System Suitability Mixture
Catalogue No.:PA 05 0731001
Molecular Formula : C42H54N6O6
Molecular Weight : 738.93
1-(2-((2R,3R,6S)-6-((2S,3E,5E,7E,9S,11R)-2,13-Dimethoxy-3,9,11-trimethyl-12-oxotrideca-3,5,7-trien-1-yl)-2-hydroxy-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylic acid;
Catalogue No.:PA 05 0731002
Molecular Weight : 591.74
2-((Tert-butyldimethylsilyl)oxy)ethyl trifluoromethanesulfonate
Catalogue No.:PAI 05 073001
Molecular Formula : C9H19F3O4SSi
Molecular Weight : 308.39
Prolyl Everolimus
Catalogue No.:PA 05 0731003
Everolimus (Y0002048)
Catalogue No.:PA EPY0002048
Molecular Formula : NA
Molecular Weight : NA
Rapamycin, 7-O-demethyl-42-O-(2-hydroxyethyl)-, (7ξ)-
Catalogue No.:PA 05 0731004
16-Demethoxy-16(R)-ethoxyeverolimus
Catalogue No.:PA 05 0731005
Molecular Weight : 972.27
(3S,6R,7E,9R,10R,12R,14R,16E,18E,20E,23S,26R,27R,34aS)-15-Ethoxy-9,27-dihydroxy-3-((R)-1-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)propan-2-yl)-10-methoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,15,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1]oxa[4]azacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentaone
Catalogue No.:PA 05 0731006
Everolimus Impurity 1
Catalogue No.:PA 05 0731007
Molecular Formula : C53H83NO15
Molecular Weight : 974.24
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