estropipate and its Impurities

Estropipate is used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis in menopausal women. It is also known as piperazine estrone sulfate and sold under the brand names Harmogen, Improvera. Reference standards of Estropipate API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.