Eltrombopag is used to treat low blood platelet counts in adults with chronic immune thrombocytopenia when certain other medicines, or surgery to remove the spleen, have not worked well enough. It has been recently approved for the treatment of thrombocytopenia in patients with chronic hepatitis C to allow them to initiate and maintain interferon-based therapy.. Reference standards of Eltrombopag API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
Eltrombopag
Catalogue No.:PA 32 22000
CAS :
Molecular Formula : C25H22N4O4
Molecular Weight : 442.47
Eltrombopag Amide
Catalogue No.:PA 32 22510
Molecular Formula : C25H23N5O3
Molecular Weight : 441.48
Eltrombopag Ethyl Ester
Catalogue No.:PA 32 22520
Molecular Formula : C27H26N4O4
Molecular Weight : 470.52
Eltrombopag Methyl Ester
Catalogue No.:PA 32 22530
Molecular Formula : C26H24N4O4
Molecular Weight : 456.49
(E)-5'-Chloro-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)-1-hydroxyhydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid
Catalogue No.:PA 32 22540
Molecular Formula : C25H21ClN4O5
Molecular Weight : 492.91
1-(4-Ethoxyphenyl)-5-(2-hydroxy-4-methoxybenzoyl)pyridin-2(1H)-one
Catalogue No.:PA 32 22550
Molecular Formula : C21H19NO5
Molecular Weight : 365.38
(E)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-methoxy-[1,1'-biphenyl]-3-carboxylic Acid
Catalogue No.:PA 32 22560
(Z)-5'-Chloro-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid
Catalogue No.:PA 32 22570
Molecular Formula : C25H21ClN4O4
Molecular Weight : 476.91
(Z)-2'-(Benzyloxy)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-[1,1'-biphenyl]-3-carboxylic Acid
Catalogue No.:PA 32 22580
Molecular Formula : C32H28N4O4
Molecular Weight : 532.59
Eltrombopag-13C4
Catalogue No.:PA STI 036900
Molecular Formula : C2113C4H22N4O4
Molecular Weight : 446.44
3'-Amino-2'-Hydroxy-[1,1']biphenyl-3-carboxylic Acid
Catalogue No.:PA 32 22590
Molecular Formula : C13H11NO3
Molecular Weight : 229.23
(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)-1-nitrosohydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
Catalogue No.:PA 32 0221000
Molecular Formula : C25H21N5O5
Molecular Weight : 471.47
2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
Catalogue No.:PA 32 0221001
Molecular Formula : C12H14N2O
Molecular Weight : 202.26
2-Aminoethyl (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-methoxy-[1,1'-biphenyl]-3-carboxylate
Catalogue No.:PA 32 0221002
Molecular Formula : C28H29N5O4
Molecular Weight : 499.57
1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one
Catalogue No.:PA 32 0221003
Eltrombopag lactose adduct
Catalogue No.:PA 32 0221004
Molecular Formula : C37H42N4O14
Molecular Weight : 766.76
(2S,3S,4S,5R)-6-((3-Acetamido-3'-carboxy-[1,1'-biphenyl]-2-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid
Catalogue No.:PA 32 0221005
Molecular Formula : C21H21NO10
Molecular Weight : 447.4
Methoxy Eltrombopag
Catalogue No.:PA 32 0221006
Molecular Weight : 456.5
(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-N-(2-hydroxyethyl)-[1,1'-biphenyl]-3-carboxamide
Catalogue No.:PA 32 0221007
Molecular Formula : C27H27N5O4
Molecular Weight : 485.54
2'-Hydroxybiphenyl-3-carboxylic Acid
Catalogue No.:PA 32 0221009
Molecular Formula : C13H10O3
Molecular Weight : 214.22
Eltrombopag N-Oxide Impurity (E-Isomer)
Catalogue No.:PA 32 0221008
Molecular Formula : C25H22N4O5
Molecular Weight : 458.47
2'-Hydroxy-3'-nitro-[1,1'-biphenyl]-3-carboxylic Acid
Catalogue No.:PA 32 0221010
Molecular Formula : C13H9NO5
Molecular Weight : 259.22
(E)-2-(3,4-Dimethylphenyl)-4-(hydroxyimino)-5-methyl-2,4-dihydro-3H-pyrazol-3-one
Catalogue No.:PA 32 0221011
Molecular Formula : C12H13N3O2
Molecular Weight : 231.26
Eltrombopag N-Oxide Impurity (Z-Isomer)
Catalogue No.:PA 32 0221012
N-Nitroso Eltrombopag Amino Impurity
Catalogue No.:PA 32 0221013
Molecular Formula : C13H10N2O4
Molecular Weight : 258.23
3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid
Catalogue No.:PA 32 0221014
Molecular Weight : 442.48
1,1'',2'-Tris(3,4-dimethylphenyl)-5,5''-dihydroxy-3,3'',5'-trimethyl-1H,1''H-[4,4':4',4''-terpyrazol]-3'(2'H)-one
Catalogue No.:PA 32 0221015
Molecular Formula : C36H38N6O3
Molecular Weight : 602.74
Eltrombopag-d9
Catalogue No.:PA STI 089437
Molecular Formula : C25H13D9N4O4
Molecular Weight : 451.53
2-(2,3-Dimethylphenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one
Catalogue No.:PA 32 0221016
3,3'-(2-Amino-3-oxo-3H-phenoxazine-4,6-diyl)dibenzoic Acid
Catalogue No.:PA 32 0221017
Molecular Formula : C26H16N2O6
Molecular Weight : 452.42
Eltrombopag dimer-1 impurity
Catalogue No.:PA 32 0221018
Molecular Formula : C52H47N9O7
Molecular Weight : 910
2-(3,4-Dimethylphenyl)-5-methyl-1-nitroso-1,2-dihydro-3H-pyrazol-3-one
Catalogue No.:PA 32 0221019
(Z)-2-(3,4-Dimethylphenyl)-4-(hydroxyimino)-5-methyl-2,4-dihydro-3H-pyrazol-3-one
Catalogue No.:PA 32 0221020
(Z)-2-(3,4-Dimethylphenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one oxime
Catalogue No.:PA 32 0221022
Molecular Formula : C12H15N3O
Molecular Weight : 217.27
3'-(2-((4Z,5Z)-1-(3,4-Dimethylphenyl)-5-(hydroxyimino)-3-methyl-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid
Catalogue No.:PA 32 0221021
Molecular Formula : C25H23N5O4
Molecular Weight : 457.49
Methyl (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)-1-hydroxyhydrazineyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate
Catalogue No.:PAI 32 022001
Molecular Formula : C26H24N4O5
Molecular Weight : 472.5
3'-Amino-2'-methoxy-[1,1'-biphenyl]-3-carboxylic Acid
Catalogue No.:PA 32 0221023
Molecular Formula : C14H13NO3
Molecular Weight : 243.26
(E)-2-(3,4-Dimethylphenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one oxime
Catalogue No.:PA 32 0221024
Methyl (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-2'-methoxy-[1,1'-biphenyl]-3-carboxylate
Catalogue No.:PAI 32 022002
Molecular Weight : 470.53
2-(3,4-Dimethylphenyl)-4-(hydroxyimino)-5-methyl-2,4-dihydro-3H-pyrazol-3-one
Catalogue No.:PA 32 0221025
Methyl (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)-1-nitrosohydrazineyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate
Catalogue No.:PA 32 0221026
Molecular Formula : C26H23N5O5
Molecular Weight : 485.5
(Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-5'-nitroso-[1,1'-biphenyl]-3-carboxylic Acid
Catalogue No.:PA 32 0221027
(E)-Eltrombopag
Catalogue No.:PA 32 0221028
2'-Hydroxy-3'-(1-nitrosohydrazineyl)-[1,1'-biphenyl]-3-carboxylic Acid
Catalogue No.:PA 32 0221029
Molecular Formula : C13H11N3O4
Molecular Weight : 273.25
3'-Hydrazineyl-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid
Catalogue No.:PA 32 0221030
Molecular Formula : C13H12N2O3
Molecular Weight : 244.25
(Z)-4-(((E)-2-Hydroxy-[1,1'-biphenyl]-3(2H)-ylidene)hydrazineylidene)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
Catalogue No.:PA 32 0221031
Molecular Formula : C21H16N4O2
Molecular Weight : 356.39
Eltrombopag Acyl Glucuronide
Catalogue No.:PA 32 0221032
Molecular Formula : C31H30N4O10
Molecular Weight : 618.6
(Z)-2'-Hydroxy-3'-(2-(5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-[1,1'-biphenyl]-3-carboxylic Acid
Catalogue No.:PA 32 0221033
Molecular Formula : C22H16N4O4
Molecular Weight : 400.39
(Z)-3,4,5-Trihydroxy-6-((2'-hydroxy-3'-(1-hydroxy-2-(5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-[1,1'-biphenyl]-3-carbonyl)oxy)tetrahydro-2H-pyran-2-carboxylic Acid
Catalogue No.:PA 32 0221034
Molecular Formula : C22H20N4O11
Molecular Weight : 516.42
Eltrombopag Olamine Ester
Catalogue No.:PA 32 0221035
2',3'-Dihydroxy-[1,1'-biphenyl]-3-carboxylic Acid
Catalogue No.:PA 32 0221036
Molecular Formula : C13H10O4
Molecular Weight : 230.22
3,4-Dimethylbenzenediazonium Chloride
Catalogue No.:PA 32 0221037
Molecular Formula : C8H9ClN2
Molecular Weight : 168.62
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