Edaravone is used to help people recover from stroke in Japan, and is used to treat ALS in the US and Japan. It is sold as under the brand names Radicava. Reference standards of Edaravone API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
Edaravone
Catalogue No.:PA 32 06000
CAS :
Molecular Formula : C10H10N2O
Molecular Weight : 174.2
4,4'-(Ethane-1,1-diyl)bis(3-methyl-1-phenyl-1H-pyrazol-5(4H)-one)
Catalogue No.:PA 32 06510
Molecular Formula : C22H22N4O2
Molecular Weight : 374.44
4,4'-(Ethane-1,1-diyl)bis(3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-ol)
Catalogue No.:PA 32 06520
Molecular Formula : C22H26N4O2
Molecular Weight : 378.47
Bispyrazolone
Catalogue No.:PA 32 06530
Molecular Formula : C20H18N4O2
Molecular Weight : 346.38
3,3'-Dimethyl-1,1'-diphenyl[4,4'-bi-1H-pyrazole]-5,5'-diol
Catalogue No.:PA 32 06540
1,2-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one
Catalogue No.:PA 32 06550
3-Methyl-1-phenyl-4,5-dihydro-1H-pyrazole-4,5-diol
Catalogue No.:PA 32 06560
Molecular Formula : C10H12N2O2
Molecular Weight : 192.21
Edaravone N-Oxide
Catalogue No.:PA 32 06570
Molecular Formula : C10H10N2O2
Molecular Weight : 190.2
2,4-Dihydro-4,4-bis(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-5-methyl-2-phenyl-3H-pyrazol-3-one;
Catalogue No.:PA 32 06580
Molecular Formula : C30H26N6O3
Molecular Weight : 518.58
5-Ethoxy-3-methyl-1-phenyl-1H-pyrazole
Catalogue No.:PA 32 06590
Molecular Formula : C12H14N2O
Molecular Weight : 202.26
(Z)-3',5-Dimethyl-3,5'-dioxo-1',2-diphenyl-1',2,3,5'-tetrahydro-[4,4'-bipyrazolylidene] 1-Oxide
Catalogue No.:PA 32 06640
Molecular Formula : C20H16N4O3
Molecular Weight : 360.37
3-Oxo-N'-phenylbutanehydrazide
Catalogue No.:PA 32 06650
Molecular Weight : 192.22
5,5"-dihydroxy-3,3",5'-trimethyl-1,1",2'-triphenyl-4,4",5,5"-tetrahydro-1H,1"H-[4,4':4',4"-terpyrazol]-3'(2'H)-one
Catalogue No.:PA 32 0061000
Molecular Formula : C30H30N6O3
Molecular Weight : 522.61
4-Ethyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
Catalogue No.:PA 32 0061001
5-(Hydroxymethyl)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
Catalogue No.:PA 32 0061002
4-Methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic Acid
Catalogue No.:PA 32 0061003
Molecular Formula : C11H10N2O3
Molecular Weight : 218.21
(E)-3-Methyl-1-phenyl-4-(1-(1-phenylhydrazinyl)buta-1,3-dien-2-yl)-1H-pyrazol-5-ol
Catalogue No.:PA 32 0061004
Molecular Formula : C20H20N4O
Molecular Weight : 332.41
5-Hydroxy-3,5',5"-trimethyl-1,2',2"-triphenyl-2",4,4",5-tetrahydro-1H,3"H-[4,4':4',4"-terpyrazole]-3',3"(2'H)-dione
Catalogue No.:PA 32 0061005
Molecular Formula : C30H28N6O3
Molecular Weight : 520.59
4-(2-Diazenyl-2-oxoethyl)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
Catalogue No.:PA 32 0061006
Molecular Formula : C12H12N4O2
Molecular Weight : 244.25
5-Methyl-2-phenyl-2,4-dihydro-3H,3'H-[4,4'-bipyrazole]-3,3'-dione
Catalogue No.:PA 32 0061007
Molecular Formula : C13H10N4O2
Molecular Weight : 254.25
5'-(Hydroxymethyl)-4,5-dimethyl-2,2'-diphenyl-2,2',4,4'-tetrahydro-3H,3'H-[4,4'-bipyrazole]-3,3'-dione
Catalogue No.:PA 32 0061008
Molecular Formula : C21H20N4O3
Molecular Weight : 376.42
3'-(Hydroxymethyl)-3"-methyl-5,5',5"-trioxo-1,1',1"-triphenyl-1',4,4",5,5',5"-hexahydro-1H,1"H-[4,4':4',4"-terpyrazole]-3-carboxylic Acid
Catalogue No.:PA 32 0061009
Molecular Formula : C30H24N6O6
Molecular Weight : 564.56
5-(Hydroxymethyl)-5',5"-dimethyl-2,2',2"-triphenyl-2,2",4,4"-tetrahydro-3H,3"H-[4,4':4',4"-terpyrazole]-3,3',3"(2'H)-trione
Catalogue No.:PA 32 0061010
Molecular Formula : C30H26N6O4
Molecular Weight : 534.58
(E)-2-Oxo-3-(2-phenylhydrazono)butanoic Acid
Catalogue No.:PA 32 0061013
Molecular Formula : C10H10N2O3
Molecular Weight : 206.2
2-(3-Methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)-2-sulfopropanoic Acid
Catalogue No.:PA 32 0061011
Molecular Formula : C13H14N2O6S
Molecular Weight : 326.32
2-(3-Methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)propane-2-sulfonic Acid
Catalogue No.:PA 32 0061012
Molecular Formula : C13H16N2O4S
Molecular Weight : 296.34
Edaravone D5
Catalogue No.:PA STI 088717
Molecular Formula : C10H5D5N2O
Molecular Weight : 179.23
(Z)-5,5'-Dimethyl-2,2'-diphenyl-[4,4'-bipyrazolylidene]-3,3'(2H,2'H)-dione
Catalogue No.:PAI 32 006001
Molecular Formula : C20H16N4O2
Molecular Weight : 344.37
Edaravone Trimer Impurity
Catalogue No.:PA 32 0061014
1-Hydroxy-2-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)propane-2-sulfonic acid, Sodium Salt
Catalogue No.:PA 32 0061018
Molecular Formula : C13H16N2NaO5S
Molecular Weight : 335.33
5'-Ethoxy-3,3'-dimethyl-1,1'-diphenyl-1H,1'H-[4,4'-bipyrazol]-5-ol
Catalogue No.:PA 32 0061019
Ethyl (E)-3-(2-phenylhydrazono)butanoate
Catalogue No.:PA 32 0061017
Molecular Formula : C12H16N2O2
Molecular Weight : 220.27
1-Hydroxy-2-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)propane-2-sulfonic Acid
Catalogue No.:PA 32 0061016
Molecular Formula : C13H16N2O5S
Molecular Weight : 312.34
Sodium 2-(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)propane-2-sulfonate
Catalogue No.:PA 32 0061015
Molecular Formula : C13H15N2NaO4S
Molecular Weight : 318.32
Edaravone Sulfate Triethylamine Salt
Catalogue No.:PA 32 0061020
Molecular Formula : C16H25N3O4S
Molecular Weight : 355.45
Norantipyrine Glucuronide
Catalogue No.:PA 32 0061021
Molecular Formula : C16H18N2O7
Molecular Weight : 350.33
3-Methyl-1-phenyl-1H-pyrazole-4,5-dione
Catalogue No.:PA 32 0061022
Molecular Formula : C10H8N2O2
Molecular Weight : 188.19
2-Oxo-3-(2-phenylhydrazono)butanoic Acid
Catalogue No.:PA 32 0061023
Edaravone Sulfate
Catalogue No.:PA 32 0061024
Molecular Formula : C10H10N2O4S
Molecular Weight : 254.26
5,5'-Dimethyl-2,2'-diphenyl-2',4'-dihydro-2H,3'H-[3,4'-bipyrazol]-3'-one
Catalogue No.:PA 32 0061025
Molecular Formula : C20H18N4O
Molecular Weight : 330.39
4-Hydroxy-5,5'-dimethyl-2,2'-diphenyl-2,2',4,4'-tetrahydro-3H,3'H-[4,4'-bipyrazole]-3,3'-dione
Catalogue No.:PA 32 0061026
Molecular Formula : C20H18N4O3
Molecular Weight : 362.39
Edaravone Dimer N-Oxide
Catalogue No.:PA 32 0061027
Ethyl 3-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)butanoate
Catalogue No.:PA 32 0061028
Molecular Formula : C16H18N2O3
Molecular Weight : 286.33
Methyl 5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carboxylate
Catalogue No.:PAI 32 006002
Molecular Formula : C12H12N2O3
Molecular Weight : 232.24
Dimethyl 3,3'-dimethyl-5,5'-dioxo-1,1'-diphenyl-1,1',5,5'-tetrahydro-4H,4'H-[4,4'-bipyrazole]-4,4'-dicarboxylate
Catalogue No.:PAI 32 006003
Molecular Formula : C24H22N4O6
Molecular Weight : 462.46
1-(p-Tolyl)-1H-pyrazol-4-ol
Catalogue No.:PA 32 0061029
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