dorzolamide and its Impurities
A carbonic anhydrase inhibitor, Dorzplamide is used for the treatment of glaucoma and ocular hypertension. It is administered as topical opthalmic form and decreases the aqueous humour production.. Reference standards of Dorzolamide API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below


(4S,6S)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-3-sulfonamide 7,7-dioxide Hydrochloride
(4S,6S)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-3-sulfonamide 7,7-dioxide Hydrochloride
Catalogue No.:PA 31 03510
CAS :
NA
Molecular Formula : C10H17ClN2O4S3
Molecular Weight : 360.9


Dorzolamide Related Compound B ((4R,6S)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyr (1225317)
Dorzolamide Related Compound B ((4R,6S)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyr (1225317)
Catalogue No.:PA USP1225317
CAS :
1417607-96-5
Molecular Formula : NA
Molecular Weight : NA


Dorzolamide Related Compound D ((4S,6S)-4-Amino-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-su (1225306)
Dorzolamide Related Compound D ((4S,6S)-4-Amino-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-su (1225306)
Catalogue No.:PA USP1225306
CAS :
164455-27-0
Molecular Formula : NA
Molecular Weight : NA


Dorzolamide Hydrochloride Related Compound A ((4R,6R)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno (1225292)
Dorzolamide Hydrochloride Related Compound A ((4R,6R)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno (1225292)
Catalogue No.:PA USP1225292
CAS :
NA
Molecular Formula : NA
Molecular Weight : NA


(4S,6S)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-3-sulfonamide 7,7-dioxide
(4S,6S)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-3-sulfonamide 7,7-dioxide
Catalogue No.:PA 04 62540
CAS :
199734-71-9
Molecular Formula : C10H16N2O4S3
Molecular Weight : 324.43


N-((4S,6S)-6-Methyl-7,7-dioxido-2-sulfamoyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-yl)acetamide
N-((4S,6S)-6-Methyl-7,7-dioxido-2-sulfamoyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-yl)acetamide
Catalogue No.:PA 31 0031000
CAS :
147200-03-1
Molecular Formula : C10H14N2O5S3
Molecular Weight : 338.41


(4R,6R)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride
(4R,6R)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride
Catalogue No.:PA 04 0621005
CAS :
120279-36-9
Molecular Formula : C10H17ClN2O4S3
Molecular Weight : 360.89


(6S)-6-Methyl-7,7-dioxido-2-sulfamoyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-yl methanesulfonate
(6S)-6-Methyl-7,7-dioxido-2-sulfamoyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-yl methanesulfonate
Catalogue No.:PAI 04 062001
CAS :
NA
Molecular Formula : C9H13NO7S4
Molecular Weight : 375.44


(E)-N'-(((4R,6R)-4-(Ethylamino)-6-methyl-7,7-dioxido-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-yl)sulfonyl)-N,N-dimethylformimidamide
(E)-N'-(((4R,6R)-4-(Ethylamino)-6-methyl-7,7-dioxido-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-yl)sulfonyl)-N,N-dimethylformimidamide
Catalogue No.:PAI 04 062003
CAS :
NA
Molecular Formula : C13H21N3O4S3
Molecular Weight : 379.51


N-((4R,6R)-2-(N-((E)-(Dimethylamino)methylene)sulfamoyl)-6-methyl-7,7-dioxido-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-yl)-N-ethylaspartic Acid
N-((4R,6R)-2-(N-((E)-(Dimethylamino)methylene)sulfamoyl)-6-methyl-7,7-dioxido-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-yl)-N-ethylaspartic Acid
Catalogue No.:PAI 04 062004
CAS :
NA
Molecular Formula : C17H25N3O8S3
Molecular Weight : 495.58


Diethyl N-ethyl-N-((4S,6S)-6-methyl-7,7-dioxido-2-sulfamoyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-yl)-L-aspartate
Diethyl N-ethyl-N-((4S,6S)-6-methyl-7,7-dioxido-2-sulfamoyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-yl)-L-aspartate
Catalogue No.:PAI 04 062005
CAS :
NA
Molecular Formula : C18H28N2O8S3
Molecular Weight : 496.61


N-((4S,6S)-6-Methyl-7,7-dioxido-2-sulfamoyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-yl)acetamide (BSC)
N-((4S,6S)-6-Methyl-7,7-dioxido-2-sulfamoyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-yl)acetamide
Catalogue No.:PA BSC 06204803
CAS :
147200-03-1
Molecular Formula : C10H14N2O5S3
Molecular Weight : 338.41