Denotivir and its Impurities

Denotivir is an isothiazole derivative of 5-amino-3-methylisothiazolocarboxylic acid I with antiviral activity against human herpes simplex viruse types 1 and 2, and varicella zoster virus. Reference standards of Denotivir API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.