Ciclosporin, also spelled cyclosporine and cyclosporin, is an immunosuppressant medication and natural product. It is approved by the FDA to treat and prevent graft-versus-host disease in bone marrow transplantation and to prevent rejection of kidney, heart, and liver transplants.. Reference standards of Cyclosporin API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
Cyclosporin
Catalogue No.:PA 03 84000
CAS :
Molecular Formula : C62H111N11O12
Molecular Weight : 1202.61
1,11-Anhydro[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-N-methyl-L-[(1S,2R)-1-hydroxy-2-methylhexyl]glycl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucylL-valyl-N-methyl-L-leucine] ([6-L-[(1S,2R)-1-hydroxy-2-methylhexyl]glycine]ciclosporin A)
Catalogue No.:PA 03 84010
Molecular Formula : C62H113N11O12
Molecular Weight : 1204.63
Cyclosporin B
Catalogue No.:PA 03 84020
Molecular Formula : C61H109N11O12
Molecular Weight : 1188.58
Cyclosporin C
Catalogue No.:PA 03 84030
Molecular Formula : C62H111N11O13
Molecular Weight : 1218.64
Cyclosporin D
Catalogue No.:PA 03 84040
Molecular Formula : C63H113N11O12
Molecular Weight : 1216.64
Cyclosporin H
Catalogue No.:PA 03 84080
Molecular Weight : 1202.63
Isociclosporin A
Catalogue No.:PA 03 84510
Cyclosporin G
Catalogue No.:PA 03 84520
Cyclosporine Resolution Mixture
Catalogue No.:PA 03 84530
Acetoxy Cyclosporin A Acetate
Catalogue No.:PA 03 84540
Molecular Formula : C66H115N11O15
Molecular Weight : 1302.7
Iso Cyclosporin H Trifluoroacetic Acid Salt
Catalogue No.:PA 03 84550
Molecular Formula : C62H111N11O12•x(C2HF3O2)
Molecular Weight : 1202.61 + x(114.02)
Cyclosporin A-d4 Acetate (Major)
Catalogue No.:PA STI 023700
Molecular Formula : C64H109D4N11O13
Molecular Weight : 1248.67
Cyclosporin A-13C2,d4 Acetate
Catalogue No.:PA STI 023710
Molecular Formula : C6213C2H109D4N11O13
Molecular Weight : 1250.65
Cyclosporin A-13C2,d4 (Major)
Catalogue No.:PA STI 023720
Molecular Formula : C6013C2H107D4N11O12
Molecular Weight : 1208.62
Cyclosporin A-d4 (Major)
Catalogue No.:PA STI 023730
Molecular Formula : C62H107D4N11O12
Molecular Weight : 1206.64
Cyclosporin B-d4
Catalogue No.:PA STI 023740
Molecular Formula : C61H105D4N11O12
Molecular Weight : 1192.58
Cyclosporin C-d4
Catalogue No.:PA STI 023750
Molecular Formula : C62H107D4N11O13
Molecular Weight : 1222.64
Cyclosporin D-d4
Catalogue No.:PA STI 023760
Molecular Formula : C63H109D4N11O12
Molecular Weight : 1220.66
Cyclosporin H-d4
Catalogue No.:PA STI 023770
Cyclosporin E
Catalogue No.:PA 03 84560
Molecular Weight : 1188.61
Cyclosporin L
Catalogue No.:PA 03 84570
Iso Cyclosporine H
Catalogue No.:PA 03 84580
Molecular Weight : 1202.64
(3S,6S,9S,12R,15S,18S,21S,24S,27R,30S,33S)-27-((2-(Dimethylamino)ethyl)thio)-30-ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-24-(2-hydroxy-2-methylpropyl)-6,9,18-triisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
Catalogue No.:PA 03 84590
Molecular Formula : C66H120N12O13S
Molecular Weight : 1321.82
(1R,2R,E)-1-((2R,5R,14S,17R,20S,23S,26R,29S,32R)-8-ethyl-14,20,29,32-Tetraisobutyl-2,17-diisopropyl-1,4,10,13,19,23,26,28,31-nonamethyl-3,9,12,15,18,21,24,27,30,35-decaoxo-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclopentatriacontan-5-yl)-2-methylhex-4-en-1-yl Acetate
Catalogue No.:PAI 03 038010
Molecular Formula : C66H119N11O12
Molecular Weight : 1258.74
Cyclosporin A Acetate
Catalogue No.:PAI 03 038020
Molecular Formula : C64H113N11O13
Molecular Weight : 1244.67
(1R,2R,E)-6-Bromo-1-((2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-ethyl-11,17,26,29-tetraisobutyl-14,32-diisopropyl-1,7,10,16,20,23,25,28,31-nonamethyl-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl)-2-methylhex-4-en-1-yl Acetate
Catalogue No.:PAI 03 038030
Molecular Formula : C64H112BrN11O13
Molecular Weight : 1323.57
Abu 5-Cyclosporin
Catalogue No.:PA 03 0841000
(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-15,30-Diethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,19,25,28-octamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
Catalogue No.:PA 03 0841001
Molecular Weight : 1216.66
Sodium 4-hydroxy-4-methyl-2-(methylamino)pentanoate
Catalogue No.:PA 03 0841003
Molecular Formula : C7H14NNaO3
Molecular Weight : 183.18
Ciclosporin D
Catalogue No.:PA 03 0840070
Molecular Formula : NA
Molecular Weight : NA
Ciclosporin V
Catalogue No.:PA 03 0840050
Cyclosporin A, 3-(4-hydroxy-N-methyl-L-leucine)
Catalogue No.:PA 03 0841004
Molecular Weight : 1218.63
Abu10-Ciclosporin A
Catalogue No.:PA 03 0840060
Cyclosporin Q
Catalogue No.:PA 03 0841005
Molecular Formula : C60H107N11O12
Molecular Weight : 1174.58
Dihydrocyclosporin H
Catalogue No.:PA 03 0841006
Molecular Weight : 1204.65
Cyclosporin AM 1
Catalogue No.:PA 03 0841007
Ciclosporin U
Catalogue No.:PA 03 0840040
Cyclosporin T
Catalogue No.:PA 03 0841008
(4S,5R)-5-((R,E)-Hex-4-en-2-yl)-3-methyl-2-oxo-N-((4S,7S,10R,13S,16S,19S,22S,28S)-4,7,16,22-tetraisobutyl-19-isopropyl-5,8,10,13,17,23,26-heptamethyl-3,6,9,12,15,18,21,24,27-nonaoxo-2,5,8,11,14,17,20,23,26-nonaazatriacontan-28-yl)oxazolidine-4-carboxamide
Catalogue No.:PA 03 0841009
Molecular Formula : C58H103N11O12
Molecular Weight : 1146.53
6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A
Catalogue No.:PA 03 0841010
Molecular Formula : C62H109N11O14
Molecular Weight : 1232.62
Benzyl N-(tert-butoxycarbonyl)-N-methylglycinate
Catalogue No.:PAI 03 038031
Molecular Formula : C15H21NO4
Molecular Weight : 279.34
Benzyl methylglycinate Hydrochloride
Catalogue No.:PAI 03 038032
Molecular Formula : C10H14ClNO2
Molecular Weight : 215.68
Benzyl (S)-N-(2-((tert-butoxycarbonyl)amino)butanoyl)-N-methylglycinate
Catalogue No.:PAI 03 038033
Molecular Formula : C19H28N2O5
Molecular Weight : 364.44
(S)-N-(2-((tert-Butoxycarbonyl)amino)butanoyl)-N-methylglycine
Catalogue No.:PAI 03 038034
Molecular Formula : C12H22N2O5
Molecular Weight : 274.32
Benzyl (S)-N-(2-((tert-butoxycarbonyl)amino)pentanoyl)-N-methylglycinate
Catalogue No.:PAI 03 038035
Molecular Formula : C20H30N2O5
Molecular Weight : 378.47
(S)-N-(2-((tert-Butoxycarbonyl)amino)pentanoyl)-N-methylglycine
Catalogue No.:PAI 03 038036
Molecular Formula : C13H24N2O5
Molecular Weight : 288.34
Benzyl N-(tert-butoxycarbonyl)-N-methyl-L-leucyl-L-alaninate
Catalogue No.:PAI 03 038037
Molecular Formula : C22H34N2O5
Molecular Weight : 406.52
Benzyl methyl-L-leucyl-L-alaninate
Catalogue No.:PAI 03 038038
Molecular Formula : C17H26N2O3
Molecular Weight : 306.41
Benzyl N-((tert-butoxycarbonyl)-L-valyl)-N-methyl-L-leucyl-L-alaninate
Catalogue No.:PAI 03 038039
Molecular Formula : C27H43N3O6
Molecular Weight : 505.66
Benzyl N-(L-valyl)-N-methyl-L-leucyl-L-alaninate
Catalogue No.:PAI 03 038040
Molecular Formula : C22H35N3O4
Molecular Weight : 405.54
Benzyl N-N-(tert-butoxycarbonyl)-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alaninate
Catalogue No.:PAI 03 038041
Molecular Formula : C34H56N4O7
Molecular Weight : 632.84
Benzyl N-methyl-N-methyl-L-leucyl-L-valyl-L-leucyl-L-alaninate
Catalogue No.:PAI 03 038042
Molecular Formula : C29H48N4O5
Molecular Weight : 532.73
Benzyl N-((tert-butoxycarbonyl)-L-alanyl)-N-methylglycinate
Catalogue No.:PAI 03 038043
Molecular Formula : C18H26N2O5
Molecular Weight : 350.42
N-((tert-Butoxycarbonyl)-L-alanyl)-N-methylglycine
Catalogue No.:PAI 03 038044
Molecular Formula : C11H20N2O5
Molecular Weight : 260.29
Ethyl (E)-2-methylhex-4-enoate
Catalogue No.:PAI 03 038045
Molecular Formula : C9H16O2
Molecular Weight : 156.23
(E)-2-Methylhex-4-enoic Acid
Catalogue No.:PAI 03 038046
Molecular Formula : C7H12O2
Molecular Weight : 128.17
(R,E)-N-((S)-2-Hydroxy-1-phenylethyl)-2-methylhex-4-enamide
Catalogue No.:PAI 03 038047
Molecular Formula : C15H21NO2
Molecular Weight : 247.34
(R,E)-2-Methylhex-4-enoic Acid
Catalogue No.:PAI 03 038048
(R,E)-1-(1H-Benzo[d][1,2,3]triazol-1-yl)-2-methylhex-4-en-1-one
Catalogue No.:PAI 03 038049
Molecular Formula : C13H15N3O
Molecular Weight : 229.28
S-Phenyl 2-(((benzyloxy)carbonyl)(methyl)amino)ethanethioate
Catalogue No.:PAI 03 038050
Molecular Formula : C17H17NO3S
Molecular Weight : 315.39
N-(tert-Butoxycarbonyl)-N-methyl-D-valine
Catalogue No.:PAI 03 038051
Molecular Formula : C11H21NO4
Molecular Weight : 231.29
Boc-D-Valine
Catalogue No.:PAI 03 038052
Molecular Formula : C10H19NO4
Molecular Weight : 217.27
S-Phenyl (4R,E)-2-(((benzyloxy)carbonyl)(methyl)amino)-4-methyl-3-oxooct-6-enethioate
Catalogue No.:PAI 03 038053
Molecular Formula : C24H27NO4S
Molecular Weight : 425.54
Benzyl methyl((4R,E)-4-methyl-1,3-dioxo-1-(phenylamino)oct-6-en-2-yl)carbamate
Catalogue No.:PAI 03 038054
Molecular Formula : C24H28N2O4
Molecular Weight : 408.5
Benzyl (tert-butoxycarbonyl)-D-valinate
Catalogue No.:PAI 03 038055
Molecular Formula : C17H25NO4
Molecular Weight : 307.39
Benzyl D-valinate 2,2,2-trifluoroacetate
Catalogue No.:PAI 03 038056
Molecular Formula : C14H18F3NO4
Molecular Weight : 321.3
Benzyl N-(tert-butoxycarbonyl)-N-methyl-L-leucyl-D-valinate
Catalogue No.:PAI 03 038057
Molecular Formula : C24H38N2O5
Molecular Weight : 434.58
Benzyl N-(N-(tert-butoxycarbonyl)-N-methyl-L-leucyl)-N-methyl-D-valinate
Catalogue No.:PAI 03 038058
Molecular Formula : C25H40N2O5
Molecular Weight : 448.6
Benzyl N-methyl-N-(methyl-L-leucyl)-D-valinate 2,2,2-trifluoroacetate
Catalogue No.:PAI 03 038059
Molecular Formula : C22H33F3N2O5
Molecular Weight : 446.51
Benzyl (6S,9S,12R)-6,9-diisobutyl-12-isopropyl-2,2,5,8,11-pentamethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate
Catalogue No.:PAI 03 038060
Molecular Formula : C32H53N3O6
Molecular Weight : 575.79
Benzyl N-methyl-N-(N-methyl-N-(methyl-L-leucyl)-L-leucyl)-D-valinate
Catalogue No.:PAI 03 038061
Molecular Formula : C27H45N3O4
Molecular Weight : 475.67
Benzyl N-(N-(N-((tert-butoxycarbonyl)-D-alanyl)-N-methyl-L-leucyl)-N-methyl-L-leucyl)-N-methyl-D-valinate
Catalogue No.:PAI 03 038062
Molecular Formula : C35H58N4O7
Molecular Weight : 646.87
N-(N-(N-((tert-Butoxycarbonyl)-D-alanyl)-N-methyl-L-leucyl)-N-methyl-L-leucyl)-N-methyl-D-valine
Catalogue No.:PA 03 0841011
Molecular Formula : C28H52N4O7
Molecular Weight : 556.75
Benzyl N-(tert-butoxycarbonyl)-N-methyl-D-valinate
Catalogue No.:PAI 03 038064
Molecular Formula : C18H27NO4
Molecular Weight : 321.42
Benzyl methyl-D-valinate Hydrochloride
Catalogue No.:PAI 03 038065
Molecular Formula : C13H20ClNO2
Molecular Weight : 257.76
Benzyl N-methyl-N-(methyl-L-leucyl)-D-valinate Hydrochloride
Catalogue No.:PAI 03 038066
Molecular Formula : C20H33ClN2O3
Molecular Weight : 384.95
Benzyl N-methyl-N-(N-methyl-N-(methyl-L-leucyl)-L-leucyl)-D-valinate Hydrochloride
Catalogue No.:PAI 03 038067
Molecular Formula : C27H46ClN3O4
Molecular Weight : 512.13
Ethyl (4R,E)-2-((diphenylmethylene)amino)-4-methyl-3-oxooct-6-enoate
Catalogue No.:PAI 03 038068
Molecular Formula : C24H27NO3
Molecular Weight : 377.48
Ethyl (4R,E)-2-amino-4-methyl-3-oxooct-6-enoate
Catalogue No.:PAI 03 038069
Molecular Formula : C11H19NO3
Molecular Weight : 213.28
Ethyl (4R,E)-4-methyl-2-(methylamino)-3-oxooct-6-enoate
Catalogue No.:PAI 03 038070
Molecular Formula : C12H21NO3
Molecular Weight : 227.3
Ethyl (3R,4R,E)-3-hydroxy-4-methyl-2-(methylamino)oct-6-enoate
Catalogue No.:PAI 03 038071
Molecular Formula : C12H23NO3
Molecular Weight : 229.32
(3R,4R,E)-3-Hydroxy-4-methyl-2-(methylamino)oct-6-enoic Acid
Catalogue No.:PAI 03 038072
Molecular Formula : C10H19NO3
Molecular Weight : 201.27
(4S,5R)-5-((R,E)-Hex-4-en-2-yl)-3-methyl-2-oxo-N-((4S,7S,10R,13S,16S,19S,22S,28S)-4,7,16,22-tetraisobutyl-19-isopropyl-8,10,13,17,23,26-hexamethyl-3,6,9,12,15,18,21,24,27-nonaoxo-2,5,8,11,14,17,20,23,26-nonaazatriacontan-28-yl)oxazolidine-4-carboxamide
Catalogue No.:PA PEP 001106
Molecular Formula : C57H101N11O12
Molecular Weight : 1132.5
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