Cobimetinib Fumarate and its Impurities

Cobimetinib Fumarate is approved for use in combination with vemurafenib (Zelboraf) for the treatment of advanced melanoma with BRAF mutation (either V600E or V600K) that cannot be removed by surgery or which has metastasized Reference standards of Cobimetinib Fumarate API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.