citalopram and its Impurities
A selective serotonin reuptake inhibitor (SSRI), Citalopram is used for the treatment of depression, obsessive–compulsive disorder and panic disorders. It exists in two enatiomeric forms S-(+)-citalopram and R-(–)-citalopram. The S enantiomer provides the anti depressant effects. Reference standards of Citalopram API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


3-(1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine Hydrobromide
3-(1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine Hydrobromide
Catalogue No.:PA 03 57580
CAS :
1332724-07-8
Molecular Formula : C19H23BrFNO
Molecular Weight : 380.29


4-[4-(dimethyl-d6-amino)-1-(4-fluorophenyl)-1-buten-1-yl]-3-(hydroxymethyl)-benzonitrile (Citalopram Olefinic Impurity)
4-[4-(dimethyl-d6-amino)-1-(4-fluorophenyl)-1-buten-1-yl]-3-(hydroxymethyl)-benzonitrile (Citalopram Olefinic Impurity)
Catalogue No.:PA STI 033740
CAS :
NA
Molecular Formula : C20H15D6FN2O
Molecular Weight : 330.43


R-Citalopram Oxalate , (R-1-[3-(dimethylamino)propyl]-1-(p-fluorophenyl)-5-phthalancarbonitrile oxal (1134142)
R-Citalopram Oxalate , (R-1-[3-(dimethylamino)propyl]-1-(p-fluorophenyl)-5-phthalancarbonitrile oxal (1134142)
Catalogue No.:PA USP1134142
CAS :
219861-53-7
Molecular Formula : NA
Molecular Weight : NA


Citalopram Related Compound F (dimethyl-(1-methyl-3,3-diphenyl-allyl)-amine hydrochloride) (1134299)
Citalopram Related Compound F (dimethyl-(1-methyl-3,3-diphenyl-allyl)-amine hydrochloride) (1134299)
Catalogue No.:PA USP1134299
CAS :
55011-89-7
Molecular Formula : NA
Molecular Weight : NA


Citalopram Related Compound D 1-(4-Fluorophenyl)-1-(3-methylaminopropyl)-1,3-dihydroisobenzofuran-5 (1134277)
Citalopram Related Compound D 1-(4-Fluorophenyl)-1-(3-methylaminopropyl)-1,3-dihydroisobenzofuran-5 (1134277)
Catalogue No.:PA USP1134277
CAS :
NA
Molecular Formula : NA
Molecular Weight : NA


Citalopram Related Compound E (1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofura (1134288)
Citalopram Related Compound E (1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofura (1134288)
Catalogue No.:PA USP1134288
CAS :
NA
Molecular Formula : NA
Molecular Weight : NA


Citalopram Related Compound H (1-(4'-fluorophenyl)-1-(3-dimethylaminopropyl)-5-bromophthalane hydro (1134222)
Citalopram Related Compound H (1-(4'-fluorophenyl)-1-(3-dimethylaminopropyl)-5-bromophthalane hydro (1134222)
Catalogue No.:PA USP1134222
CAS :
479065-02-6
Molecular Formula : NA
Molecular Weight : NA


Citalopram Related Compound A (1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofura (1134244)
Citalopram Related Compound A (1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofura (1134244)
Catalogue No.:PA USP1134244
CAS :
64372-56-1
Molecular Formula : NA
Molecular Weight : NA


Citalopram Related Compound G (1-(4'-fluorophenyl)-1-(3-dimethylaminopropyl)-5-chlorophthalane hydr (1134197)
Citalopram Related Compound G (1-(4'-fluorophenyl)-1-(3-dimethylaminopropyl)-5-chlorophthalane hydr (1134197)
Catalogue No.:PA USP1134197
CAS :
NA
Molecular Formula : NA
Molecular Weight : NA


Citalopram Related Compound B (1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3-hydroxy-1,3-dihydro (1134255)
Citalopram Related Compound B (1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3-hydroxy-1,3-dihydro (1134255)
Catalogue No.:PA USP1134255
CAS :
NA
Molecular Formula : NA
Molecular Weight : NA


Citalopram Related Compound C (3-(3-Dimethylaminopropyl)-3-(4-fluorophenyl)-6-cyano-1(3H)-isobenzof (1134266)
Citalopram Related Compound C (3-(3-Dimethylaminopropyl)-3-(4-fluorophenyl)-6-cyano-1(3H)-isobenzof (1134266)
Catalogue No.:PA USP1134266
CAS :
NA
Molecular Formula : NA
Molecular Weight : NA


1-(3-(1,3-Dioxoisoindolin-2-yl)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
1-(3-(1,3-Dioxoisoindolin-2-yl)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
Catalogue No.:PAI 03 002040
CAS :
345663-52-7
Molecular Formula : C26H19FN2O3
Molecular Weight : 426.45


3-(((tert-Butyldimethylsilyl)oxy)methyl)-4-(4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)benzonitrile
3-(((tert-Butyldimethylsilyl)oxy)methyl)-4-(4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)benzonitrile
Catalogue No.:PAI 03 002060
CAS :
1370643-24-5
Molecular Formula : C26H37FN2O2Si
Molecular Weight : 456.67


1-(2-(((tert-Butyldimethylsilyl)oxy)methyl)-4-cyanophenyl)-4-(dimethylamino)-1-(4-fluorophenyl)butyl methanesulfonate
1-(2-(((tert-Butyldimethylsilyl)oxy)methyl)-4-cyanophenyl)-4-(dimethylamino)-1-(4-fluorophenyl)butyl methanesulfonate
Catalogue No.:PAI 03 002070
CAS :
NA
Molecular Formula : C27H39FN2O4SSi
Molecular Weight : 534.76


3-(((tert-Butyldimethylsilyl)oxy)methyl)-4-(4-(dimethylamino)-1-(4-fluorophenyl)but-1-en-1-yl)benzonitrile
3-(((tert-Butyldimethylsilyl)oxy)methyl)-4-(4-(dimethylamino)-1-(4-fluorophenyl)but-1-en-1-yl)benzonitrile
Catalogue No.:PAI 03 002080
CAS :
NA
Molecular Formula : C26H35FN2OSi
Molecular Weight : 438.65


3,3'-((Methylenebis(oxy))bis(methylene))bis(4-(4-(dimethylamino)-1-(4-fluorophenyl)butyl)benzonitrile)
3,3'-((Methylenebis(oxy))bis(methylene))bis(4-(4-(dimethylamino)-1-(4-fluorophenyl)butyl)benzonitrile)
Catalogue No.:PA 03 57700
CAS :
NA
Molecular Formula : C41H46F2N4O2
Molecular Weight : 664.84


4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile Hydrochloride
4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile Hydrochloride
Catalogue No.:PA 30 94530
CAS :
717133-25-0
Molecular Formula : C20H24ClFN2O2
Molecular Weight : 378.87


(+/-)-4-[4-(diMethylaMino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxyMethyl)-benzonitrile, oxalate
(+/-)-4-[4-(diMethylaMino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxyMethyl)-benzonitrile, oxalate
Catalogue No.:PA 56 0801000
CAS :
717133-32-9
Molecular Formula : C22H25FN2O6
Molecular Weight : 432.45


1-Chloroethyl (3-(5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)propyl)(methyl)carbamate
1-Chloroethyl (3-(5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)propyl)(methyl)carbamate
Catalogue No.:PAI 03 002511
CAS :
1025972-63-7
Molecular Formula : C22H22ClFN2O3
Molecular Weight : 416.88


4-(4-Cyano-2-(hydroxymethyl)phenyl)-4-(4-fluorophenyl)-4-hydroxy-N,N-dimethylbutan-1-amine oxide
4-(4-Cyano-2-(hydroxymethyl)phenyl)-4-(4-fluorophenyl)-4-hydroxy-N,N-dimethylbutan-1-amine oxide
Catalogue No.:PA 56 0801006
CAS :
NA
Molecular Formula : C20H23FN2O3
Molecular Weight : 358.41