Ceftolozane and its Impurities
Ceftolozane/tazobactam, sold under the brand name Zerbaxa, is a combination antibiotic medication used for the treatment of complicated urinary tract infections and complicated intra-abdominal infections in adults. Reference standards of Ceftolozane API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


tert-Butyl (Z)-2-(((2-amino-1-(5-amino-1,2,4-thiadiazol-3-yl)-2-oxoethylidene)amino)oxy)-2-methylpropanoate
tert-Butyl (Z)-2-(((2-amino-1-(5-amino-1,2,4-thiadiazol-3-yl)-2-oxoethylidene)amino)oxy)-2-methylpropanoate
Catalogue No.:PA 03 4351001
CAS :
NA
Molecular Formula : C12H19N5O4S
Molecular Weight : 329.38


(E)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)acetic Acid
(E)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)acetic Acid
Catalogue No.:PA 03 4351002
CAS :
NA
Molecular Formula : C12H18N4O5S
Molecular Weight : 330.36


4-Methoxybenzyl (6R,7R)-7-amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
4-Methoxybenzyl (6R,7R)-7-amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Catalogue No.:PA 03 4351003
CAS :
47288-83-5
Molecular Formula : C16H18N2O4S
Molecular Weight : 334.39


3-Chloro-4-methoxybenzyl (6R,7R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
3-Chloro-4-methoxybenzyl (6R,7R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Catalogue No.:PA 03 4351004
CAS :
1950566-51-4
Molecular Formula : C16H16Cl2N2O4S
Molecular Weight : 403.27


(2R,6R,7R,Z)-7-((Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-3-((5-amino-4-(3-(2-aminoethyl)ureido)-1-methyl-1H-pyrazol-2-ium-2-yl)methylene)-8-oxo-5-thia-1-azabicyclo[4.2.0]octane-2-carboxylate
(2R,6R,7R,Z)-7-((Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-3-((5-amino-4-(3-(2-aminoethyl)ureido)-1-methyl-1H-pyrazol-2-ium-2-yl)methylene)-8-oxo-5-thia-1-azabicyclo[4.2.0]octane-2-carboxylate
Catalogue No.:PA 03 4351007
CAS :
1956303-45-9
Molecular Formula : C23H30N12O8S2
Molecular Weight : 666.69


Benzhydryl (6R,7R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Benzhydryl (6R,7R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Catalogue No.:PA 03 4351008
CAS :
56040-80-3
Molecular Formula : C21H19ClN2O3S
Molecular Weight : 414.9


(6R,7R)-3-((5-Amino-4-(3-(2-aminoethyl)ureido)-1-methyl-1H-pyrazol-2-ium-2-yl)methyl)-7-(methylsulfonamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
(6R,7R)-3-((5-Amino-4-(3-(2-aminoethyl)ureido)-1-methyl-1H-pyrazol-2-ium-2-yl)methyl)-7-(methylsulfonamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Catalogue No.:PA 03 4351009
CAS :
1956303-47-1
Molecular Formula : C16H24N8O6S2
Molecular Weight : 488.54


(Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)acetic Acid
(Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)acetic Acid
Catalogue No.:PA 03 4351010
CAS :
76028-96-1
Molecular Formula : C12H18N4O5S
Molecular Weight : 330.36


(Z)-2-(((1-(5-Amino-1,2,4-thiadiazol-3-yl)-2-((2,2-dihydroxyethyl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoic Acid
(Z)-2-(((1-(5-Amino-1,2,4-thiadiazol-3-yl)-2-((2,2-dihydroxyethyl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoic Acid
Catalogue No.:PA 03 4351011
CAS :
1956303-56-2
Molecular Formula : C10H15N5O6S
Molecular Weight : 333.32


(Z)-2-(((2-Amino-1-(5-amino-1,2,4-thiadiazol-3-yl)-2-oxoethylidene)amino)oxy)-2-methylpropanoic Acid
(Z)-2-(((2-Amino-1-(5-amino-1,2,4-thiadiazol-3-yl)-2-oxoethylidene)amino)oxy)-2-methylpropanoic Acid
Catalogue No.:PA 03 4351012
CAS :
1956303-48-2
Molecular Formula : C8H11N5O4S
Molecular Weight : 273.27


(Z)-2-(((1-(5-Amino-1,2,4-thiadiazol-3-yl)-2-((carboxymethyl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoic Acid
(Z)-2-(((1-(5-Amino-1,2,4-thiadiazol-3-yl)-2-((carboxymethyl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoic Acid
Catalogue No.:PA 03 4351013
CAS :
1956303-49-3
Molecular Formula : C10H13N5O6S
Molecular Weight : 331.3


(2R,6R,7R)-7-((Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-3-((5-amino-4-(3-(2-aminoethyl)ureido)-1-methyl-1H-pyrazol-2-ium-2-yl)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylate
(2R,6R,7R)-7-((Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-3-((5-amino-4-(3-(2-aminoethyl)ureido)-1-methyl-1H-pyrazol-2-ium-2-yl)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylate
Catalogue No.:PA 03 4351014
CAS :
1956303-44-8
Molecular Formula : C23H30N12O8S2
Molecular Weight : 666.69


(6R,7R)-7-((E)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-3-((5-amino-4-(3-(2-aminoethyl)ureido)-1-methyl-1H-pyrazol-2-ium-2-yl)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
(6R,7R)-7-((E)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-3-((5-amino-4-(3-(2-aminoethyl)ureido)-1-methyl-1H-pyrazol-2-ium-2-yl)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Catalogue No.:PA 03 4351015
CAS :
1852466-67-1
Molecular Formula : C23H30N12O8S2
Molecular Weight : 666.69