According to recent phase 3 randomized trials, a cangrelor–clopidogrel combination is safe and has been found to be more effective than standard clopidogrel treatment at reducing ischemic events in the heart, without increasing major bleeding in the treatment of stenotic coronary arteries. It is a P2Y12 inhibitor FDA approved as of June 2015 as an antiplatelet drug for intravenous application. Reference standards of Cangrelor API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
Cangrelor
Catalogue No.:PA 30 91000
CAS :
Molecular Formula : C17H25Cl2F3N5O12P3S2
Molecular Weight : 776.36
N-(2-(Methylthio)ethyl)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-6-amine
Catalogue No.:PA 30 91510
Molecular Formula : C11H14F3N5S2
Molecular Weight : 337.39
2-Thioadenosine
Catalogue No.:PA 30 91520
Molecular Formula : C10H13N5O4S
Molecular Weight : 299.31
2-[(3,3,3-Trifluoropropyl)thio]-adenosine
Catalogue No.:PA 30 91530
Molecular Formula : C13H16F3N5O4S
Molecular Weight : 395.36
N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-adenosine 2',3',5'-triacetate
Catalogue No.:PA 30 91540
Molecular Formula : C22H28F3N5O7S2
Molecular Weight : 595.61
N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-adenosine, 5'-(hydrogen P-1H-imidazol-1-ylphosphonate)
Catalogue No.:PA 30 91550
Molecular Formula : C16H23F3N5O7PS2
Molecular Weight : 549.48
N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-adenosine (9CI)
Catalogue No.:PA 30 91560
Molecular Formula : C16H22F3N5O4S2
Molecular Weight : 469.5
Cangrelor Tetrasodium Salt
Catalogue No.:PA 30 91570
Molecular Formula : C17H21Cl2F3N5Na4O12P3S2
Molecular Weight : 864.29
((2R,3S,4R,5R)-3,4-Dihydroxy-5-(6-((2-(methylthio)ethyl)amino)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl hydrogen 1H-imidazol-1-ylphosphonate
Catalogue No.:PA 30 91580
Molecular Formula : C19H25F3N7O6PS2
Molecular Weight : 599.54
(2R,3R,4R,5R)-2-(6-Acetamido-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)-5-(acetoxymethyl)tetrahydrofuran-3,4-diyl Diacetate
Catalogue No.:PA 30 0911000
Molecular Formula : C21H24F3N5O8S
Molecular Weight : 563.51
(2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(6-(N-(2-(methylthio)ethyl)acetamido)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl Diacetate
Catalogue No.:PA 30 0911001
Molecular Formula : C24H30F3N5O8S2
Molecular Weight : 637.65
Cangrelor Sulfoxide Sodium Salt
Catalogue No.:PA 30 0911002
Molecular Formula : C17H21Cl2F3N5Na4O13P3S2
Molecular Weight : 880.27
Cangrelor Dimer
Catalogue No.:PA 30 0911003
Molecular Formula : C33H46Cl2F6N10O18P4S4
Molecular Weight : 1307.81
((2S,3R,4S,5S)-3,4-Dihydroxy-5-(6-((2-(methylthio)ethyl)amino)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl Dihydrogen Phosphate
Catalogue No.:PA 30 0911004
N-Nitroso-Cangrelor
Catalogue No.:PA 30 0911005
Molecular Formula : C17H24Cl2F3N6O13P3S2
Molecular Weight : 805.34
N-(9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-6-yl)-N-(2-(methylthio)ethyl)nitrous amide
Catalogue No.:PA 30 0911008
Molecular Formula : C16H21F3N6O5S2
Molecular Weight : 498.5
N-Nitroso-Cangrelor Tetrasodium Salt
Catalogue No.:PA 30 0911009
Molecular Formula : C17H24Cl2F3N6Na4O13P3S2
Molecular Weight : 897.3
N-Nitroso Cangrelor Sulfoxide Tetrsodium Salt
Catalogue No.:PA 30 0911010
Molecular Formula : C17H24Cl2F3N6Na4O16P3S2
Molecular Weight : 945.3
N-(2-(Methylsulfinyl)ethyl)-N-(2-((3,3,3-trifluoropropyl)thio)-9H-purin-6-yl)nitrous amide
Catalogue No.:PA 30 0911011
Molecular Formula : C11H13F3N6O2S2
Molecular Weight : 382.38
N-(2-(Methylsulfinyl)ethyl)-N-(9-nitroso-2-((3,3,3-trifluoropropyl)thio)-9H-purin-6-yl)nitrous amide
Catalogue No.:PA 30 0911012
Molecular Formula : C11H12F3N7O3S2
Molecular Weight : 411.38
((2R,3S,4R,5R)-3,4-Dihydroxy-5-(6-((2-(methylthio)ethyl)(nitroso)amino)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl dihydrogen phosphate
Catalogue No.:PA 30 0911013
Molecular Formula : C16H22F3N6O8PS2
Molecular Weight : 578.47
Catalogue No.:PA 30 0911014
N-(2-(Methylthio)ethyl)-N-(2-((3,3,3-trifluoropropyl)thio)-9H-purin-6-yl)nitrous amide
Catalogue No.:PA 30 0911015
Molecular Formula : C11H13F3N6OS2
Molecular Weight : 366.38
N-(2-(Methylthio)ethyl)-N-(9-nitroso-2-((3,3,3-trifluoropropyl)thio)-9H-purin-6-yl)nitrous amide
Catalogue No.:PA 30 0911016
Molecular Formula : C11H12F3N7O2S2
Molecular Weight : 395.38
N-(2-(Methylsulfinyl)ethyl)-2-((3,3,3-trifluoropropyl)thio)-9H-purin-6-amine
Catalogue No.:PA 30 0911017
Molecular Formula : C11H14F3N5OS2
Molecular Weight : 353.38
Cangrelor Monophosphoryl Dimer Impurity
Catalogue No.:PA 30 0911018
Molecular Formula : C32H44F6N10O13P2S4
Molecular Weight : 1080.9
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