Cabozantinib is used in two forms. A capsule form is used since 2012 to treat medullary thyroid cancer and a tablet form is used since 2016 as a second line treatment for renal cell carcinoma.. Reference standards of Cabozantinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
Cabozantinib
Catalogue No.:PA 30 62000
CAS :
Molecular Formula : C28H24FN3O5
Molecular Weight : 501.51
Cabozantinib Hydroxy Analog
Catalogue No.:PA 30 0621002
Molecular Formula : C11H11NO3
Molecular Weight : 205.21
Cabozantinib Nitro Analog
Catalogue No.:PA 30 62540
Molecular Formula : C17H14N2O5
Molecular Weight : 326.3
Cabozantinib Amine Analog
Catalogue No.:PA 30 62550
Molecular Formula : C17H16N2O3
Molecular Weight : 296.32
Cabozantinib L-Malate
Catalogue No.:PA 30 62590
Molecular Formula : C32H30FN3O10
Molecular Weight : 635.59
1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic Acid
Catalogue No.:PA 30 62600
Molecular Formula : C11H10FNO3
Molecular Weight : 223.2
N-(4-Fluorophenyl)-n'-(4-hydroxyphenyl)cyclopropane-1,1-dicarboxamide
Catalogue No.:PA 30 62610
Molecular Formula : C17H15FN2O3
Molecular Weight : 314.31
Cabozantinib Dimer Impurity
Catalogue No.:PA 30 62620
Molecular Formula : C36H30N4O8
Molecular Weight : 646.65
4-Fluoroaniline Hydrochloride
Catalogue No.:PA 30 0621000
Molecular Formula : C6H7ClFN
Molecular Weight : 147.58
3,4-Dimethoxyaniline Hydrochloride
Catalogue No.:PA 30 0621001
Molecular Formula : C8H12ClNO2
Molecular Weight : 189.64
Cabozantinib Carboxylic Acid Analog
Catalogue No.:PA 30 0621004
Molecular Formula : C22H20N2O6
Molecular Weight : 408.4
N,N'-Bis(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;
Catalogue No.:PA 30 0621005
Molecular Formula : C17H14F2N2O2
Molecular Weight : 316.31
Cabozantinib Desfluoro Impurity
Catalogue No.:PA 30 0621006
Molecular Formula : C28H25N3O5
Molecular Weight : 483.52
1-((4-((7-Methoxy-6-(sulfooxy)quinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylic Acid
Catalogue No.:PA 30 0621010
Molecular Formula : C21H18N2O9S
Molecular Weight : 474.44
N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluoro-2-hydroxyphenyl)cyclopropane-1,1-dicarboxamide
Catalogue No.:PA 30 0621011
Molecular Formula : C28H24FN3O6
Molecular Weight : 517.51
N,N'-bis(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)cyclopropane-1,1-dicarboxamide
Catalogue No.:PA 30 0621013
Molecular Formula : C39H34N4O8
Molecular Weight : 686.72
N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(2-fluorophenyl)cyclopropane-1,1-dicarboxamide
Catalogue No.:PA 30 0621012
Cabozantinib N-oxide
Catalogue No.:PA 30 0621003
4-Chloro-6,7-dimethoxyquinoline
Catalogue No.:PA 30 0621007
Molecular Formula : C11H10ClNO2
Molecular Weight : 223.66
Methyl 1-((4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylate
Catalogue No.:PA 30 0621008
Molecular Formula : C23H22N2O6
Molecular Weight : 422.44
Ethyl 1-((4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylate
Catalogue No.:PA 30 0621009
Molecular Formula : C24H24N2O6
Molecular Weight : 436.46
N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(3-fluorophenyl)cyclopropane-1,1-dicarboxamide
Catalogue No.:PA 30 0621014
Cabozantinib-d4
Catalogue No.:PA STI 089396
Molecular Formula : C28H20D4FN3O5
Molecular Weight : 505.54
6,7-Dimethoxy-4-(2-nitrophenoxy)quinoline
Catalogue No.:PA 30 0621015
Molecular Weight : 326.31
3-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline
Catalogue No.:PA 30 0621016
Molecular Weight : 296.33
6,7-Dimethoxy-4-(3-nitrophenoxy)quinoline
Catalogue No.:PA 30 0621017
1-(Phenylcarbamoyl)cyclopropane-1-carboxylic Acid
Catalogue No.:PA 30 0621018
1-((3-Fluorophenyl)carbamoyl)cyclopropane-1-carboxylic Acid
Catalogue No.:PA 30 0621019
1-((2-Fluorophenyl)carbamoyl)cyclopropane-1-carboxylic Acid
Catalogue No.:PA 30 0621020
2-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline
Catalogue No.:PA 30 0621021
N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-6,7-dimethoxyquinolin-4-amine
Catalogue No.:PA 30 0621022
3,4-Dimethoxyaniline
Catalogue No.:PA 30 0621023
Molecular Formula : C8H11NO2
Molecular Weight : 153.18
N-(4-Fluorophenyl)-N-(4-((7-hydroxy-6-methoxyquinolin-4-yl)oxy)phenyl)cyclopropane-1,1-dicarboxamide
Catalogue No.:PA 30 0621024
Molecular Formula : C27H22FN3O5
Molecular Weight : 487.49
N-(4-Fluorophenyl)-N-(4-((6-hydroxy-7-methoxyquinolin-4-yl)oxy)phenyl)cyclopropane-1,1-dicarboxamide
Catalogue No.:PA 30 0621025
4-(4-Aminophenoxy)-6-methoxyquinolin-7-ol
Catalogue No.:PA 30 0621026
Molecular Formula : C16H14N2O3
Molecular Weight : 282.3
4-(4-Aminophenoxy)-7-methoxyquinolin-6-ol
Catalogue No.:PA 30 0621027
1-((3,4-Difluorophenyl)carbamoyl)cyclopropane-1-carboxylic Acid
Catalogue No.:PA 30 0621028
Molecular Formula : C11H9F2NO3
Molecular Weight : 241.19
Methyl 1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carboxylate
Catalogue No.:PA 30 0621029
Molecular Formula : C12H12FNO3
Molecular Weight : 237.23
(2S,3S,4S,5R,6S)-6-((4-(4-(1-((4-Fluorophenyl)carbamoyl)cyclopropane-1-carboxamido)phenoxy)-6-methoxyquinolin-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid
Catalogue No.:PA 30 0621030
Molecular Formula : C33H30FN3O11
Molecular Weight : 663.61
4-((6,7-Dimethoxyquinolin-4-yl)amino)phenol
Catalogue No.:PA 30 0621031
(E)-N-(3-(4,5-Dimethoxy-2-nitrophenyl)-3-oxoprop-1-en-1-yl)-N-methylnitrous amide
Catalogue No.:PA 30 0621032
Molecular Formula : C12H13N3O6
Molecular Weight : 295.25
4-((4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)amino)-3-((4-fluorophenyl)carbamoyl)-4-oxobutyl (Z)-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carbimidate
Catalogue No.:PA 30 0621033
Molecular Formula : C56H48F2N6O10
Molecular Weight : 1003.03
5-(((3,4-Dimethoxyphenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
Catalogue No.:PA 30 0621034
Molecular Formula : C15H17NO6
Molecular Weight : 307.3
Cabozantinib Methyl Ester Analog
Catalogue No.:PA 30 0621035
Molecular Weight : 422.43
Cabozantinib Ethyl Ester Analog
Catalogue No.:PA 30 0621036
Cabozantinib-D6
Catalogue No.:PA STI 089763
Molecular Formula : C28H18D6FN3O5
Molecular Weight : 507.55
N1-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N3-(4-fluorophenyl)-2-(2-hydroxyethyl)malonamide
Catalogue No.:PA 30 0621037
Molecular Formula : C28H26FN3O6
Molecular Weight : 519.53
(2S)-4-(4-((4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)amino)-3-((4-fluorophenyl)carbamoyl)-4-oxobutoxy)-2-hydroxy-4-oxobutanoic Acid
Catalogue No.:PA 30 0621038
Molecular Weight : 635.6
Cabozantinib L-Malate Salt
Catalogue No.:PA BSC 06230258
N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)-N-methylcyclopropane-1,1-dicarboxamide
Catalogue No.:PA 30 0621039
Molecular Formula : C29H26FN3O5
Molecular Weight : 515.54
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