Binimetinib and its Impurities
Binimetinib, also known as Mektovi and ARRY-162. It is used to treat a type of skin cancer.Reference standards of Binimetinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


5-((4-Bromo-2-fluorophenyl)amino)-N'-(5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carbonyl)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carbohydrazide
5-((4-Bromo-2-fluorophenyl)amino)-N'-(5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carbonyl)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carbohydrazide
Catalogue No.:PA 02 1851007
CAS :
NA
Molecular Formula : C30H20Br2F4N8O2
Molecular Weight : 760.35


N-(2-(Aminooxy)ethoxy)-5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxamide
N-(2-(Aminooxy)ethoxy)-5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxamide
Catalogue No.:PA 02 1851008
CAS :
NA
Molecular Formula : C17H16BrF2N5O3
Molecular Weight : 456.25


N,N'-(Ethane-1,2-diylbis(oxy))bis(5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxamide)
N,N'-(Ethane-1,2-diylbis(oxy))bis(5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxamide)
Catalogue No.:PA 02 1851009
CAS :
NA
Molecular Formula : C32H24Br2F4N8O4
Molecular Weight : 820.4


1,3-Dioxoisoindolin-2-yl 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate
1,3-Dioxoisoindolin-2-yl 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate
Catalogue No.:PA 02 1851010
CAS :
NA
Molecular Formula : C23H13BrF2N4O4
Molecular Weight : 527.28


1-(4-Bromo-2-fluorophenyl)-8-fluoro-5-methyl-1,5-dihydro-3H-imidazo[4',5':4,5]benzo[1,2-c]isoxazol-3-one
1-(4-Bromo-2-fluorophenyl)-8-fluoro-5-methyl-1,5-dihydro-3H-imidazo[4',5':4,5]benzo[1,2-c]isoxazol-3-one
Catalogue No.:PA 02 1851011
CAS :
NA
Molecular Formula : C15H8BrF2N3O2
Molecular Weight : 380.15


Ethyl 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate
Ethyl 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate
Catalogue No.:PA 02 1851012
CAS :
2509103-99-3
Molecular Formula : C17H14BrF2N3O2
Molecular Weight : 410.22


5-((4-Bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-N-(2-(vinyloxy)ethoxy)-1H-benzo[d]imidazole-6-carboxamide
5-((4-Bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-N-(2-(vinyloxy)ethoxy)-1H-benzo[d]imidazole-6-carboxamide
Catalogue No.:PA 02 1851017
CAS :
1415559-75-9
Molecular Formula : C19H17BrF2N4O3
Molecular Weight : 467.27


4-Fluoro-5-((2-fluorophenyl)amino)-1-methyl-N-(2-(vinyloxy)ethoxy)-1H-benzo[d]imidazole-6-carboxamide
4-Fluoro-5-((2-fluorophenyl)amino)-1-methyl-N-(2-(vinyloxy)ethoxy)-1H-benzo[d]imidazole-6-carboxamide
Catalogue No.:PA 02 1851021
CAS :
2649854-88-4
Molecular Formula : C19H18F2N4O3
Molecular Weight : 388.37


5-((4-Bromo-2-fluorophenyl)amino)-N-(2-ethoxyethoxy)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxamide
5-((4-Bromo-2-fluorophenyl)amino)-N-(2-ethoxyethoxy)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxamide
Catalogue No.:PA 02 1851023
CAS :
NA
Molecular Formula : C19H19BrF2N4O3
Molecular Weight : 469.29


5-(4-Bromo-2-fluorophenyl)-4-fluoro-7-(2-hydroxyethoxy)-1,6-dimethyl-1,5,6,7-tetrahydro-8H-imidazo[4,5-g]quinazolin-8-one
5-(4-Bromo-2-fluorophenyl)-4-fluoro-7-(2-hydroxyethoxy)-1,6-dimethyl-1,5,6,7-tetrahydro-8H-imidazo[4,5-g]quinazolin-8-one
Catalogue No.:PA 02 1851026
CAS :
NA
Molecular Formula : C19H17BrF2N4O3
Molecular Weight : 467.27


2-((5-((4-Bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxamido)oxy)ethyl acetate
2-((5-((4-Bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxamido)oxy)ethyl acetate
Catalogue No.:PA 02 1851027
CAS :
NA
Molecular Formula : C19H17BrF2N4O4
Molecular Weight : 483.27


5-((4-Bromo-2-fluorophenyl)amino)-4-fluoro-N-hydroxy-1-methyl-1H-benzo[d]imidazole-6-carboxamide
5-((4-Bromo-2-fluorophenyl)amino)-4-fluoro-N-hydroxy-1-methyl-1H-benzo[d]imidazole-6-carboxamide
Catalogue No.:PA 02 1851029
CAS :
NA
Molecular Formula : C15H11BrF2N4O2
Molecular Weight : 397.18