Bicyclomycin and its Impurities

Bicyclomycin has been used to treat diarrhea in humans and bacterial diarrhea in calves and pigs and is marketed by Fujisawa (Osaka, Japan) under the trade name Bicozamycin. Reference standards of Bicyclomycin API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.