bendamustine hydrochloride and its Impurities
An alkylating agent with chemical formula 1Hbenzimidazole-2-butanoic acid, 5-[bis(2-chloroethyl)amino]-1 methyl-, monohydrochloride. It contains a mechlorethamine group and a benzimidazole heterocyclic ring with a butyric acid substituent. It is used for the treatment of chronic lymphocytic leukemia and lymphomas. Reference standards of Bendamustine Hydrochloride API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

![5-[(2-Chloroethyl)(2-hydroxyethyl)amino]-1-methyl- PA 02 07600](https://www.pharmaffiliates.com/pimages/PA0207600.jpg)
5-[(2-Chloroethyl)(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic Acid 1-Methylethyl Ester
5-[(2-Chloroethyl)(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic Acid 1-Methylethyl Ester
Catalogue No.:PA 02 07600
CAS :
1797008-41-3
Molecular Formula : C19H28ClN3O3
Molecular Weight : 381.9


4-(6-(2-Chloroethyl)-3-methyl-3,6,7,8-tetrahydroimidazo[4',5':5,6]benzo[1,2-b][1,4]thiazin-2-yl)butanoic Acid
4-(6-(2-Chloroethyl)-3-methyl-3,6,7,8-tetrahydroimidazo[4',5':5,6]benzo[1,2-b][1,4]thiazin-2-yl)butanoic Acid
Catalogue No.:PA 02 07610
CAS :
191939-34-1
Molecular Formula : C16H20ClN3O2S
Molecular Weight : 353.87


2,3-Dihydroxypropyl 4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate
2,3-Dihydroxypropyl 4-(5-(bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate
Catalogue No.:PA 02 07660
CAS :
NA
Molecular Formula : C19H27Cl2N3O4
Molecular Weight : 432.34


2-((2-Hydroxyethyl)(2-(4-isopropoxy-4-oxobutyl)-1-methyl-1H-benzo[d]imidazol-5-yl)amino)ethyl 4-(5-(bis(2-hydroxyethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate
2-((2-Hydroxyethyl)(2-(4-isopropoxy-4-oxobutyl)-1-methyl-1H-benzo[d]imidazol-5-yl)amino)ethyl 4-(5-(bis(2-hydroxyethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate
Catalogue No.:PA 02 07700
CAS :
NA
Molecular Formula : C35H50N6O7
Molecular Weight : 666.81


4-[6-(2-Chloroethyl)-3,6,7,8-tetrahydro-3-methylimidazo[4,5-h][1,4]benzothiazin-2-yl]butanoic Acid Hydrochloride
4-[6-(2-Chloroethyl)-3,6,7,8-tetrahydro-3-methylimidazo[4,5-h][1,4]benzothiazin-2-yl]butanoic Acid Hydrochloride
Catalogue No.:PA 02 07800
CAS :
2469039-29-8
Molecular Formula : C16H21Cl2N3O2S
Molecular Weight : 390.32