beclomethasone and its Impurities
Beclomethasone is a prodrug of the free form, beclometasone. It is used for the treatment of asthma (in form of inhaler), dermatitis and psoriasis (in form of cream), ulcerative colitis (in form of pills) and allergic rhinitis and nasal polyps (in form of nasal spray). It is a steroidal drug. Reference standards of Beclomethasone API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


(8S,9R,10S,11S,13S,14S,16S,17R,E)-9-Chloro-11-hydroxy-N,10,13,16-tetramethyl-17-(propionyloxy)-17-(2-(propionyloxy)acetyl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-imine Oxide
(8S,9R,10S,11S,13S,14S,16S,17R,E)-9-Chloro-11-hydroxy-N,10,13,16-tetramethyl-17-(propionyloxy)-17-(2-(propionyloxy)acetyl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-imine Oxide
Catalogue No.:PAI 02 005001
CAS :
NA
Molecular Formula : C29H40ClNO7
Molecular Weight : 550.09


(8S,9R,10S,11S,13S,14S,16S,17R,Z)-9-Chloro-11-hydroxy-10,13,16-trimethyl-3-(methylimino)-17-(2-(propionyloxy)acetyl)-8,9,10,11,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl Propionate
(8S,9R,10S,11S,13S,14S,16S,17R,Z)-9-Chloro-11-hydroxy-10,13,16-trimethyl-3-(methylimino)-17-(2-(propionyloxy)acetyl)-8,9,10,11,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl Propionate
Catalogue No.:PAI 02 005002
CAS :
NA
Molecular Formula : C29H38ClNO6
Molecular Weight : 532.07


(8S,9R,10S,11S,13S,14S,16S,17R)-9-Chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-(propionyloxy)acetyl)-8,9,10,11,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl Propionate
(8S,9R,10S,11S,13S,14S,16S,17R)-9-Chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-(propionyloxy)acetyl)-8,9,10,11,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl Propionate
Catalogue No.:PAI 02 005003
CAS :
1448780-88-8
Molecular Formula : C28H35ClO7
Molecular Weight : 519.03


(6S,8S,9R,10S,11S,13S,14S,16S,17R)-9-Chloro-6,11-dihydroxy-10,13,16-trimethyl-3-oxo-17-(2-(propionyloxy)acetyl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl Propionate
(6S,8S,9R,10S,11S,13S,14S,16S,17R)-9-Chloro-6,11-dihydroxy-10,13,16-trimethyl-3-oxo-17-(2-(propionyloxy)acetyl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl Propionate
Catalogue No.:PAI 02 005004
CAS :
NA
Molecular Formula : C28H37ClO8
Molecular Weight : 537.05


(6S,8S,9R,10S,11S,13S,14S,16S,17R)-6-Bromo-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-(propionyloxy)acetyl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
(6S,8S,9R,10S,11S,13S,14S,16S,17R)-6-Bromo-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-(propionyloxy)acetyl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
Catalogue No.:PAI 02 005005
CAS :
887130-69-0
Molecular Formula : C28H36BrClO7
Molecular Weight : 599.94


(8S,9S,10R,13S,14S,17R)-6-Chloro-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-9,10,12,13,14,15,16,17-octahydro-3H-cyclopenta[a]phenanthrene-3,11(8H)-dione
(8S,9S,10R,13S,14S,17R)-6-Chloro-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-9,10,12,13,14,15,16,17-octahydro-3H-cyclopenta[a]phenanthrene-3,11(8H)-dione
Catalogue No.:PA 29 0101000
CAS :
5383-20-0
Molecular Formula : C21H23ClO5
Molecular Weight : 390.86


2-((10S,13S,16S,17R)-17-Hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl propionate
2-((10S,13S,16S,17R)-17-Hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl propionate
Catalogue No.:PA 29 0101002
CAS :
52618-96-9
Molecular Formula : C25H32O5
Molecular Weight : 412.53


2-((9R,10S,11S,13S,16S,17R)-9-Bromo-11-(formyloxy)-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
2-((9R,10S,11S,13S,16S,17R)-9-Bromo-11-(formyloxy)-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
Catalogue No.:PA 29 0101003
CAS :
1564242-51-8
Molecular Formula : C25H31BrO7
Molecular Weight : 523.42


(4aS,4bS,5aS,6aS,7R,8S,9aS,9bS)-2'-Ethoxy-2'-ethyl-4a,6a,8-trimethyl-5a,6,6a,8,9,9a,9b,10-octahydro-11H-spiro[cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,4'-[1,3]dioxane]-2,5'(4aH)-dione
(4aS,4bS,5aS,6aS,7R,8S,9aS,9bS)-2'-Ethoxy-2'-ethyl-4a,6a,8-trimethyl-5a,6,6a,8,9,9a,9b,10-octahydro-11H-spiro[cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,4'-[1,3]dioxane]-2,5'(4aH)-dione
Catalogue No.:PAI 02 005007
CAS :
79595-43-0
Molecular Formula : C27H36O6
Molecular Weight : 456.58