Asciminib, sold under the brand name Scemblix, is a medication used to treat Philadelphia chromosome-positive chronic myeloid leukemia. It is a protein kinase inhibitor. Reference standards of Asciminib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Asciminib
Catalogue No.:PA 01 3630000
CAS :
Molecular Formula : C20H18ClF2N5O3
Molecular Weight : 449.84
(R)-N-(4-(Chlorodifluoromethoxy)phenyl)-6-(3-hydroxypyrrolidin-1-yl)-N-nitroso-5-(1H-pyrazol-3-yl)nicotinamide
Catalogue No.:PA 01 3631000
Molecular Formula : C20H17ClF2N6O4
Molecular Weight : 478.84
Deschloro Asciminib Impurity
Catalogue No.:PA 01 3631001
Molecular Formula : C20H19F2N5O3
Molecular Weight : 415.4
(R)-6-(3-Hydroxypyrrolidin-1-yl)-5-(1H-pyrazol-3-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide
Catalogue No.:PA 01 3631002
Molecular Formula : C20H18F3N5O3
Molecular Weight : 433.39
Asciminib S-Isomer
Catalogue No.:PA 01 3631003
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