Apremilast may also be useful for other immune system related inflammatory diseases.. Reference standards of Apremilast API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
Apremilast
Catalogue No.:PA 28 24000
CAS :
Molecular Formula : C22H24N2O7S
Molecular Weight : 460.50
Apremilast Acetamido-sulfone Impurity
Catalogue No.:PA 28 24510
Molecular Formula : C14H21NO5S
Molecular Weight : 315.39
Apremilast 2-Acetamido Benzoic Acid Imurity
Catalogue No.:PA 28 24520
Molecular Formula : C22H26N2O8S
Molecular Weight : 478.52
Apremilast 3-Acetamido Benzoic Acid Imurity
Catalogue No.:PA 28 24530
N-[2-[(1S)-1-(3-Ethoxy-4-hydroxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide
Catalogue No.:PA 28 24540
Molecular Formula : C21H22N2O7S
Molecular Weight : 446.47
N-(1,3-Dioxo-1,3-dihydroisobenzofuran-5-yl)acetamide
Catalogue No.:PA 28 24650
Molecular Formula : C10H7NO4
Molecular Weight : 205.17
5-Aminoisobenzofuran-1,3-dione
Catalogue No.:PA 28 24660
Molecular Formula : C8H5NO3
Molecular Weight : 163.13
O3-Desethyl Apremilast
Catalogue No.:PA 28 24710
Molecular Formula : C20H20N2O7S
Molecular Weight : 432.45
O4-Desmethyl O3-Desethyl Apremilast
Catalogue No.:PA 28 24720
Molecular Formula : C19H18N2O7S
Molecular Weight : 418.42
N,N'-(2,2'-((Propane-1,3-diyldisulfonyl)bis(2-(3-ethoxy-4-methoxyphenyl)ethane-2,1-diyl))bis(1,3-dioxoisoindoline-4,2-diyl))diacetamide
Catalogue No.:PA 28 24730
Molecular Formula : C45H48N4O14S2
Molecular Weight : 933.01
Apremilast-d5
Catalogue No.:PA STI 008241
Molecular Formula : C22H19D5N2O7S
Molecular Weight : 465.53
N,N'-(((Propane-1,3-diyldisulfonyl)bis(1-(3-ethoxy-4-methoxyphenyl)ethane-2,1-diyl))bis(1,3-dioxoisoindoline-2,4-diyl))diacetamide
Catalogue No.:PA 28 24740
N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-((2-hydroxyethyl)sulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
Catalogue No.:PA 28 24750
Molecular Formula : C23H26N2O8S
Molecular Weight : 490.53
2-Acetamido-6-((1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)carbamoyl)benzoic Acid
Catalogue No.:PA 28 24760
(R)-Apremilast
Catalogue No.:PA 28 24770
Molecular Weight : 460.5
3-Acetamidophthalic Acid
Catalogue No.:PA 28 24780
Molecular Formula : C10H9NO5
Molecular Weight : 223.18
(S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine acetyl-L-leucinate
Catalogue No.:PA 28 24790
Molecular Formula : C20H34N2O7S
Molecular Weight : 446.56
Des-acetyl Apremilast
Catalogue No.:PA 28 24800
Molecular Formula : C20H22N2O6S
Molecular Weight : 418.46
Nitro Apremilast
Catalogue No.:PA 28 24810
Molecular Formula : C20H20N2O8S
Molecular Weight : 448.45
1-(3-Ethoxy-4-methoxy-phenyl)-2-methanesulfonylethylamine
Catalogue No.:PA 28 0241001
Molecular Formula : C12H19NO4S
Molecular Weight : 273.35
5-Acetamido-2-((1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)carbamoyl)benzoic Acid
Catalogue No.:PA 28 0241002
N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide
Catalogue No.:PA 28 0241000
4-Amino-2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione
Catalogue No.:PA 28 0241003
(S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-7-hydroxy-1,3-dioxoisoindolin-4-yl)acetamide
Catalogue No.:PA 28 0241004
Molecular Formula : C22H24N2O8S
Molecular Weight : 476.5
2-Ethoxy-1-methoxy-4-(2-methylsulfonylethenyl)benzene
Catalogue No.:PA 28 0241005
Molecular Formula : C12H16O4S
Molecular Weight : 256.32
N-Desacetyl O4-desmethyl O3-desethyl apremilast
Catalogue No.:PA 28 0241006
Molecular Formula : C17H16N2O6S
Molecular Weight : 376.38
(1S)-1-(3-Ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethylamine
Catalogue No.:PA 28 0241007
(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-5-hydroxy-1,3-dioxoisoindolin-4-yl)acetamide
Catalogue No.:PA 28 0241008
(S)-N-(2'-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,1',3,3'-tetraoxo-[2,4'-biisoindolin]-4-yl)acetamide
Catalogue No.:PA 28 0241009
Molecular Formula : C30H27N3O9S
Molecular Weight : 605.62
4-Amino-2'-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-[2,4'-biisoindoline]-1,1',3,3'-tetraone
Catalogue No.:PA 28 0241017
Molecular Formula : C28H25N3O8S
Molecular Weight : 563.58
4-Acetyl-2-(1-(3,4-dimethoxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione
Catalogue No.:PA 28 0241010
Molecular Formula : C21H21NO7S
Molecular Weight : 431.46
N-(2-(1-(4-Ethoxy-3-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
Catalogue No.:PA 28 0241011
2-Amino-6-((1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)carbamoyl)benzoic acid
Catalogue No.:PA 28 0241012
Molecular Formula : C20H24N2O7S
Molecular Weight : 436.48
(S)-2-Acetamido-N-((S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-4-methylpentanamide
Catalogue No.:PA 28 0241013
Molecular Formula : C20H32N2O6S
Molecular Weight : 428.54
(S)-4-Amino-2-(1-(3-ethoxy-4-hydroxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione
Catalogue No.:PA 28 0241014
Molecular Formula : C19H20N2O6S
Molecular Weight : 404.44
1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-ol
Catalogue No.:PA 28 0241015
Molecular Formula : C12H18O5S
Molecular Weight : 274.33
(Z)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethen-1-amine
Catalogue No.:PA 28 0241016
Molecular Formula : C12H17NO4S
Molecular Weight : 271.33
Apremilast D8
Catalogue No.:PA STI 088911
Molecular Formula : C22H16D8N2O7S
Molecular Weight : 468.55
3-Hydroxy-4-methoxybenzonitrile
Catalogue No.:PA 28 0241018
Molecular Formula : C8H7NO2
Molecular Weight : 149.15
3-Ethoxy-4-methoxybenzonitrile
Catalogue No.:PA 28 0241019
Molecular Formula : C10H11NO2
Molecular Weight : 177.2
(S)-2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione
Catalogue No.:PA 28 0241020
Molecular Formula : C20H21NO6S
Molecular Weight : 403.45
(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-5-yl)acetamide
Catalogue No.:PA 28 0241021
(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)formamide
Catalogue No.:PA 28 0241022
Sodium (S)-2-acetamido-6-((1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)carbamoyl)benzoate
Catalogue No.:PA 28 0241023
Molecular Formula : C22H25N2NaO8S
Molecular Weight : 500.5
O-Desmethyl apremilast glucuronide sodium salt
Catalogue No.:PA 28 0241024
Molecular Formula : C26H27N2NaO13S
Molecular Weight : 630.55
(E)-3-Ethoxy-4-methoxybenzaldehyde oxime
Catalogue No.:PA 28 0241030
Molecular Formula : C10H13NO3
Molecular Weight : 195.22
1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanimine
Catalogue No.:PA 28 0241034
1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanone
Catalogue No.:PA 28 0241031
Molecular Formula : C12H16O5S
Molecular Weight : 272.32
5-(1-Amino-2-(methylsulfonyl)ethyl)-2-methoxyphenol
Catalogue No.:PA 28 0241032
Molecular Formula : C10H15NO4S
Molecular Weight : 245.29
4-(1-Amino-2-(methylsulfonyl)ethyl)-2-ethoxyphenol
Catalogue No.:PA 28 0241033
Molecular Formula : C11H17NO4S
Molecular Weight : 259.32
1-(3,4-Dimethoxyphenyl)-2-(methylsulfonyl)ethanamine
Catalogue No.:PA 28 0241029
1-(3,4-Diethoxyphenyl)-2-(methylsulfonyl)ethanamine
Catalogue No.:PA 28 0241028
Molecular Formula : C13H21NO4S
Molecular Weight : 287.37
4-(1-Amino-2-(methylsulfonyl)ethyl)benzene-1,2-diol
Catalogue No.:PA 28 0241027
Molecular Formula : C9H13NO4S
Molecular Weight : 231.27
2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-4-nitroisoindoline-1,3-dione
Catalogue No.:PA 28 0241026
N-(2-(1-(3,4-Diethoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
Catalogue No.:PA 28 0241025
Molecular Formula : C23H26N2O7S
Molecular Weight : 474.53
3-Aminophthalimide
Catalogue No.:PA 28 0241035
Molecular Formula : C8H6N2O2
Molecular Weight : 162.15
(S)-4-Amino-2-(1-(3-hydroxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione
Catalogue No.:PA 28 0241036
Molecular Formula : C18H18N2O6S
Molecular Weight : 390.41
(S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine (S)-5-oxopyrrolidine-2-carboxylate
Catalogue No.:PA 28 0241037
Molecular Formula : C17H26N2O7S
Molecular Weight : 402.46
N-Nitroso Apremilast
Catalogue No.:PA 28 0241038
Molecular Formula : C22H23N3O8S
Molecular Weight : 489.5
N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)-N-nitrosoacetamide
Catalogue No.:PA 28 0241039
Molecular Formula : C10H6N2O5
Molecular Weight : 234.17
(S)-5-Amino-2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione
Catalogue No.:PA 28 0241040
(S)-2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-5-nitroisoindoline-1,3-dione
Catalogue No.:PA 28 0241041
(Z)-N-(3-Ethoxy-4-methoxybenzyl)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethen-1-amine
Catalogue No.:PA 28 0241042
Molecular Formula : C22H29NO6S
Molecular Weight : 435.54
N-(3-Ethoxy-4-methoxybenzyl)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine
Catalogue No.:PA 28 0241043
Molecular Formula : C22H31NO6S
Molecular Weight : 437.55
O-Desmethyl Apremilast Glucuronide
Catalogue No.:PA 28 0241044
Molecular Formula : C27H30N2O13S
Molecular Weight : 622.6
2-Ethoxy-1-methoxy-4-(2-(methylsulfonyl)ethyl)benzene
Catalogue No.:PA 28 0241045
Molecular Formula : C12H18O4S
Molecular Weight : 258.33
2-Ethoxy-4-(1-isopropoxy-2-(methylsulfonyl)ethyl)-1-methoxybenzene
Catalogue No.:PA 28 0241046
Molecular Formula : C15H24O5S
Molecular Weight : 316.41
1-(3-Ethoxy-4-methoxyphenyl)-2-((2-hydroxyethyl)sulfonyl)ethan-1-one
Catalogue No.:PA 28 0241047
Molecular Formula : C13H18O6S
Molecular Weight : 302.34
2-((2-Amino-2-(3-ethoxy-4-methoxyphenyl)ethyl)sulfonyl)ethan-1-ol
Catalogue No.:PA 28 0241048
Molecular Formula : C13H21NO5S
Molecular Weight : 303.37
(R)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine
Catalogue No.:PA 28 0241049
Apremilast (IPRSA037)
Catalogue No.:PA IPRSA037
Molecular Formula : NA
Molecular Weight : NA
3-(4-Acetamido-1,3-dioxoisoindolin-2-yl)phthalic Acid
Catalogue No.:PA 28 0241050
Molecular Formula : C18H12N2O7
Molecular Weight : 368.3
N-(3-Ethoxy-4-methoxybenzyl)-N-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)nitrous amide
Catalogue No.:PA 28 0241051
Molecular Formula : C22H30N2O7S
Molecular Weight : 466.55
(E)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethen-1-amine
Catalogue No.:PA 28 0241052
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