afatinib is a protein kinase inhibitor, it is used for the treatment of patients with distinct types of metastatic (EGFR mutation positive) non-small cell lung carcinoma (NSCLC), developed by Boehringer Ingelheim. It is also known as Gilotrif and Giotrif. Reference standards of Afatinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Afatinib
Catalogue No.:PA 28 02000
CAS :
Molecular Formula : C24H25ClFN5O3
Molecular Weight : 485.94
N-(3,4-dichlorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
Catalogue No.:PA 28 02510
Molecular Formula : C14H7Cl2FN4O2
Molecular Weight : 353.14
(S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
Catalogue No.:PA 28 02520
Molecular Formula : C18H17FN4O2
Molecular Weight : 340.35
(S)-N4-phenyl-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
Catalogue No.:PA 28 02530
Molecular Formula : C18H18N4O2
Molecular Weight : 322.36
(S)-N4-(3-chlorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
Catalogue No.:PA 28 02540
Molecular Formula : C18H17ClN4O2
Molecular Weight : 356.81
(S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
Catalogue No.:PA 28 02550
Molecular Formula : C18H16ClFN4O2
Molecular Weight : 374.8
(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)formamide
Catalogue No.:PA 28 02560
Molecular Formula : C19H16ClFN4O3
Molecular Weight : 402.81
(S)-N-(((4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)methylene)-N-methylmethanaminium
Catalogue No.:PA 28 02570
Molecular Formula : C21H22ClFN5O2
Molecular Weight : 430.88
1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one
Catalogue No.:PA 28 02580
Molecular Formula : C22H20ClFN4O4
Molecular Weight : 458.87
(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide
Catalogue No.:PA 28 02590
Molecular Formula : C24H27ClFN5O4
Molecular Weight : 503.95
(R)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide
Catalogue No.:PA 28 02600
(S,E)-N-(4-((4-Chloro-3-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 28 02610
(S,E)-4-(Dimethylamino)-N-(4-((4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide
Catalogue No.:PA 28 02620
Molecular Formula : C24H26FN5O3
Molecular Weight : 451.49
(S,Z)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 28 02630
(R)-Afatinib
Catalogue No.:PA 28 02640
(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine
Catalogue No.:PA 28 02650
Molecular Formula : C18H14ClFN4O4
Molecular Weight : 404.78
(S,E)-N-(4-((3,4-Difluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 28 02660
Molecular Formula : C24H25F2N5O3
Molecular Weight : 469.48
(S,E)-N-(4-((4-Chloro-3-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide
Catalogue No.:PA 28 02670
Molecular Formula : C22H20ClFN4O3
Molecular Weight : 442.87
(S,E)-N-(4-((3,4-Dichlorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 28 02680
Molecular Formula : C24H25Cl2N5O3
Molecular Weight : 502.39
(S,E)-4-Bromo-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide
Catalogue No.:PA 28 02690
Molecular Formula : C22H19BrClFN4O3
Molecular Weight : 521.77
(S,E)-4-(Dimethylamino)-N-(4-hydroxy-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide
Catalogue No.:PA 28 02700
Molecular Formula : C18H22N4O4
Molecular Weight : 358.39
(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(methylamino)but-2-enamide
Catalogue No.:PA 28 02710
Molecular Formula : C23H23ClFN5O3
Molecular Weight : 471.91
(S,E)-4-((4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-2-yl)oxy)quinazolin-6-yl)amino)-N,N-dimethyl-4-oxobut-2-en-1-amine oxide
Catalogue No.:PA 28 02720
Molecular Formula : C24H25ClFN5O4
Molecular Weight : 501.94
(E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 28 02730
Molecular Formula : C22H23ClFN5O2
Molecular Weight : 443.9
(E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 28 02740
Molecular Formula : C21H21ClFN5O2
Molecular Weight : 429.88
(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-hydroxybut-2-enamide
Catalogue No.:PA 28 02760
(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-3-enamide
Catalogue No.:PA 28 02770
N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine
Catalogue No.:PA 28 02780
Molecular Formula : C15H10ClFN4O3
Molecular Weight : 348.72
(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide
Catalogue No.:PA 28 02800
N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide
Catalogue No.:PA 28 02810
Afatinib-d4
Catalogue No.:PA STI 004270
Molecular Formula : C24H21D4ClFN5O3
Molecular Weight : 489.96
Afatinib-d6
Catalogue No.:PA STI 004271
Molecular Formula : C24H19D6ClFN5O3
Molecular Weight : 491.98
1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-2-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one
Catalogue No.:PA 28 02820
Afatinib-d6 Dimaleate (N,N-dimethyl-d6)
Catalogue No.:PA STI 088303
Molecular Formula : C32H27D6ClFN5O11
Molecular Weight : 724.13
(2E)-N-[3,4-Dihydro-4-oxo-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
Catalogue No.:PA 28 0021000
Molecular Weight : 358.40
4-N-(3-Chloro-4-fluorophenyl)-7-[(3R)-oxolan-3-yl]oxyquinazoline-4,6-diamine
Catalogue No.:PA 28 0021001
Afatinib Maleic acid Adduct
Catalogue No.:PA 28 0021002
Molecular Formula : C28H29ClFN5O7
Molecular Weight : 602.02
N-(4-chloro-3-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
Catalogue No.:PA 28 0021003
Molecular Formula : C14H7ClF2N4O2
Molecular Weight : 336.68
4-Dimethylaminobut-2-ynoic Acid Hydrochloride
Catalogue No.:PA 28 0021004
Molecular Formula : C6H10ClNO2
Molecular Weight : 163.6
(R)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine
Catalogue No.:PA 28 0021005
(S,Z)-N-(4-((3,4-Dichlorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 28 0021006
Molecular Weight : 502.4
(S)-N4-(3,4-Difluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
Catalogue No.:PA 28 0021007
Molecular Formula : C18H16F2N4O2
Molecular Weight : 358.35
(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((R)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide
Catalogue No.:PA 28 0021008
Molecular Weight : 503.96
(R)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((R)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide
Catalogue No.:PA 28 0021009
Diethyl (S)-(2-((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-2-oxoethyl)phosphonate
Catalogue No.:PA 28 0021011
Molecular Formula : C24H27ClFN4O6P
Molecular Weight : 552.92
4-((4-Chloro-3-fluorophenyl)amino)-6-nitroquinazolin-7-ol
Catalogue No.:PA 28 0021012
Molecular Formula : C14H8ClFN4O3
Molecular Weight : 334.69
(S)-N-(4-((4-Fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)formamide
Catalogue No.:PA 28 0021010
Molecular Formula : C19H17FN4O3
Molecular Weight : 368.37
N-(4-Chloro-3-fluorophenyl)-7-fluoro-8-nitroquinazolin-4-amine
Catalogue No.:PA 28 0021013
(S,E)-N-(4-((3-Chloro-4-fluorophenyl)(nitroso)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 28 0021014
Molecular Formula : C24H24ClFN6O4
Molecular Weight : 514.94
(S,Z)-N-(4-((4-Chloro-3-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 28 0021015
N-(3,4-Difluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
Catalogue No.:PA 28 0021016
Molecular Formula : C14H7F3N4O2
Molecular Weight : 320.23
4-((3-Chloro-4-fluorophenyl)amino)-6-nitroquinazolin-7-ol
Catalogue No.:PA 28 0021017
(S)-N4-(3,4-Dichlorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
Catalogue No.:PA 28 0021018
Molecular Formula : C18H16Cl2N4O2
Molecular Weight : 391.25
1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((R)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one
Catalogue No.:PA 28 0021019
3-(2-Pyridyl)-5,6-bis(4-sulfophenyl)-1,2,4-trazine Disodium Salt Hydrate
Catalogue No.:PA 28 0021020
Molecular Formula : C20H16N4Na2O7S2
Molecular Weight : 534.47
N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-3,4-bis(dimethylamino)butanamide
Catalogue No.:PA 28 0021021
Molecular Formula : C26H32ClFN6O3
Molecular Weight : 531.03
(E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-hydroxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 28 0021022
Molecular Formula : C20H19ClFN5O2
Molecular Weight : 415.85
N1,N2-Bis(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)oxalamide
Catalogue No.:PA 28 0021023
Molecular Formula : C38H30Cl2F2N8O6
Molecular Weight : 803.6
(S)-N1-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-N2,N2-dimethyloxalamide
Catalogue No.:PA 28 0021024
Molecular Formula : C22H21ClFN5O4
Molecular Weight : 473.89
Afatinib N-Oxide
Catalogue No.:PA 28 0021025
3-((3-Chloro-4-fluorophenyl)amino)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)butanamide
Catalogue No.:PA 28 0021026
Molecular Formula : C30H30Cl2F2N6O2
Molecular Weight : 615.51
N-(4-((3-Chloro-4-Fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)amino)-4-(piperidin-1-yl)butanamide
Catalogue No.:PA 28 0021027
Molecular Formula : C39H37Cl2F2N9O3
Molecular Weight : 788.68
(S,E)-2-((3-Chloro-4-fluorophenyl)(6-(4-(dimethylamino)but-2-enamido)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-yl)amino)malonic acid
Catalogue No.:PA 28 0021028
Molecular Formula : C27H27ClFN5O7
Molecular Weight : 587.99
(R)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 28 0021029
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