afatinib dimaleate and its Impurities

Afatinib Dimaleate received regulatory approval for use as a treatment for non-small cell lung cancer, although there is emerging evidence to support its use in other cancers such as breast cancer. Afatinib, sold under the brand name Gilotrif among others, is a medication used to treat non-small cell lung carcinoma. Reference standards of Afatinib Dimaleate API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.