LY 2228820-d9

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Catalogue number:	PA STI 057340
Chemical name:	LY 2228820-d9
CAS Number:	NA
Category:	stable isotopes,miscellaneous compounds
Synonyms:	5-[2-(1,1-Dimethylethyl-d9)-5-(4-fluorophenyl)-1H-imidazol-4-yl]-3-(2,2-dimethylpropyl)-3H-imidazo[4,5-b]pyridin-2-amine Dimethanesulfonate;
Molecular form:	C₂₆H₂₈D₉FN₆O₆S₂
Appearance:	NA
Mol. Weight:	621.79
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	Laballed LY2228820, a novel and potent p38MAPK inhibitor with potent antiinflammatory activity. LY2228820 significantly inhibited phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, in both multiple myeloma (MM) cell lines and LT-BMSCs. LY2228820 is a potential candidate to improve MM patient outcome both by enhancing the effect of Bortezomib and by reducing osteoskeletal events.

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