Name: Abacavir Sulfate - Impurity D (Dihydrochloride Salt)
Brand: Pharmaffliates
Rating: 4.50 (5 reviews)

Catalogue number:	PA 01 01040
Chemical name:	trans-Abacavir Dihydrochloride
CAS Number:	NA
Alternate CAS Number:	1443421-67-7 (Freebase)
Similar Products:	1443421-67-7(Freebase);NA(HCl Salt)
Category:	intermediates,pharmaceutical standards,enzyme inhibitors,Fine Chemicals,bases and related reagents,nucleotides
Synonyms:	(1R,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Diydrochloride; ((1R,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol Dihydrochloride;
Molecular form:	C₁₄H₂₀Cl₂N₆O
Appearance:	Pale Yellow to Pale Orange Solid
Mol. Weight:	359.25
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

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Abacavir Sulfate - Impurity D (Dihydrochloride Salt)

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