trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene-d8

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Catalogue number:	PA STI 032740
Chemical name:	trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene-d8
CAS Number:	861441-06-7
Category:	miscellaneous compounds,stable isotopes
Synonyms:	(7R,8R)-rel-7,8-Dihydrobenzo[a]pyrene-1,2,3,4,5,6,11,12-d8-7,8-diol; Benzo[a]pyrene-1,2,3,4,5,6,11,12-d8-7,8-diol, 7,8-dihydro-, (7R,8R);
Molecular form:	C₂₀H₆D₈O₂
Appearance:	NA
Mol. Weight:	294.37
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	Labelled trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene is a metabolite of Benzopyrene. Benzo[a]pyrene, a prototypic PAH, is metabolized by cytochrome P 450 1A1/1B1. (-)-trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene undergoes further P 4501A1/1B1-mediated metabolism to a carcinogen, which forms DNA-adducts primarily with 2'-deoxyguanosine. A carcinogen.