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Catalogue number: PA PHY 004102
Chemical name: EURYCOMANONE

CAS Number:

84633-29-4

Category: NA
Synonyms:

1,20-Epoxy-1,11,12,14,15-pentahydroxy-(1ß,11ß,12a,15ß)-Picrasa-3,13(21)-diene-2,16-dione; NSC 339187; Pasakbumin A; (1ß,11ß,12a,15ß)-11,20-Epoxy-1,11,12,14,15-pentahydroxypicrasa-3,13(21)-diene-2,16-dione; Picrasa-3,13(21)-diene-2,16-dione, 11,20-epoxy-1,11,12,14,15-pentahydroxy-, (1ß,11ß,12a,15ß); (1R,2R,3aR,3a1R,4R,6aR,7aS,11S,11aS,11bR)-1,2,3a,4,11-pentahydroxy-8,11a-dimethyl-3-methylene-1,2,3,3a,4,7,7a,11,11a,11b-decahydro-5H-1,3a1-(epoxymethano)dibenzo[de,g]chromene-5,10(6aH)-dione;

Molecular form: C20H24O9
Appearance: Off-White Solid
Mol. Weight: 408.4
Storage: 2-8°C Refrigerator
Shipping Conditions: Ambient
Applications: Eurycomanone is known as a cytotoxic compound found in Eurycoma Longifolia Jack. Previous studies had noted its cytotoxic effects against various cancer cell lines. More recent research demonstrated the ability of Eurycomanone to suppress the expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28. Eurycomanone was shown to also exerts the ability to induce apoptosis through the up-regulation of p53 in human cervical carcinoma cells.

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