Name: DM4-SMe
Brand: Pharmaffliates
Rating: 4.00 (5 reviews)

Catalogue number:	PA 40 0421002
Chemical name:	DM4-SMe
CAS Number:	796073-68-2
Category:	amines,aromatics,heterocycles,pharmaceutical standards,intermediates,Fine Chemicals,sulphur and selenium compounds,Antibody Drug Conjugate
Synonyms:	(14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-methyl-N-(4-methyl-4-(methyldisulfaneyl)pentanoyl)-L-alaninate; Maytansine, N2′-deacetyl-N2′-[4-methyl-4-(methyldithio)-1-oxopentyl]-;
Molecular form:	C₃₉H₅₆ClN₃O₁₀S₂
Appearance:	Solid
Mol. Weight:	826.46
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM

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DM4-SMe

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