Name: Tanespimycin - API Standards
Brand: Pharmaffliates
Rating: 4.50 (5 reviews)

Catalogue number:	PA 20 3490000
Chemical name:	Tanespimycin
CAS Number:	75747-14-7
Category:	enzyme inhibitors,pharmaceutical standards,intermediates,enzyme activators
Synonyms:	(4Z,6E,8S,9S,10E,12S,13R,14S,16R)-19-(Allylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate; Geldanamycin, 17-demethoxy-17-(2-propenylamino); 17-Demethoxy-17-(2-propenylamino)geldanamycin; 17-(Allylamino)-17-demethoxygeldanamycin; 17-(Allylamino)geldanamycin; 17-N-Allylamino-17-demethoxygeldanamycin;
Molecular form:	C₃₁H₄₃N₃O₈
Appearance:	Dark Red to Very Dark Red Solid
Mol. Weight:	585.7
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.

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