| Catalogue number: | PA 20 3490000 |
| Chemical name: | Tanespimycin |
CAS Number: |
75747-14-7 |
| Category: | enzyme inhibitors,pharmaceutical standards,intermediates,enzyme activators |
| Synonyms: | (4Z,6E,8S,9S,10E,12S,13R,14S,16R)-19-(Allylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate; Geldanamycin, 17-demethoxy-17-(2-propenylamino); 17-Demethoxy-17-(2-propenylamino)geldanamycin; 17-(Allylamino)-17-demethoxygeldanamycin; 17-(Allylamino)geldanamycin; 17-N-Allylamino-17-demethoxygeldanamycin; |
| Molecular form: | C31H43N3O8 |
| Appearance: | Dark Red to Very Dark Red Solid |
| Mol. Weight: | 585.7 |
| Storage: | 2-8°C Refrigerator |
| Shipping Conditions: | Ambient |
| Applications: | Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. |
Tanespimycin
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