Name: Methylnaltrexone Bromide
Brand: Pharmaffliates
Rating: 3.50 (5 reviews)

Catalogue number:	PA 14 0081000
Chemical name:	Methylnaltrexone Bromide
CAS Number:	73232-52-7
Category:	impurities,metabolites,pharmaceutical standards,intermediates,Fine Chemicals
Synonyms:	(17RS)-17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium Bromide; N-Methyl Naltrexone Bromide; 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium Bromide;
Molecular form:	C₂₁H₂₆BrNO₄
Appearance:	White to Pale Brown Solid
Mol. Weight:	436.35
Storage:	2-8°C Hygroscopic, Refrigerator, Under Inert Atmosphere
Shipping Conditions:	Ambient
Applications:	A metabolite of Naltrexone. Methylnaltrexone, a selective μ-opioid receptor (MOR) antagonist, functions as a peripherally acting receptor antagonist in tissues of the gastrointestinal tract. When opiates activate μ-opioid receptors (MORs) they trigger signaling pathways that lead to tolerance and hyperalgesia. Methylnaltrexone is positively charged and therefore does not cross the blood brain barier. Mice given morphine with methylnaltrexone experienced pain relief without degeloping tolerance.

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Methylnaltrexone Bromide

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