(+/-)-Blebbistatin

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Catalogue number:	PA 27 0016946
Chemical name:	(+/-)-Blebbistatin
CAS Number:	674289-55-5
Category:	miscellaneous compounds
Synonyms:	3a-Hydroxy-6-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one;
Molecular form:	C₁₈H₁₆N₂O₂
Appearance:	Yellow Solid
Mol. Weight:	292.34
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100µM.(±)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one_x000B__x000B_Selective inhibitor of nonmuscle myosin II; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.