Teriflunomide-3-isomer

In House Impurity

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Catalogue number:	PA 47 0391009
Chemical name:	Teriflunomide-3-isomer
CAS Number:	62004-05-1
Category:	intermediates,impurities,pharmaceutical standards,Fine Chemicals,metabolites,tyrosine kinase inhibitors
Synonyms:	2-Cyano-3-hydroxy-N-[3-(trifluoromethyl)phenyl]-2-butenamide; 2-Butenamide, 2-cyano-3-hydroxy-N-[3-(trifluoromethyl)phenyl]-;
Molecular form:	C₁₂H₉F₃N₂O₂
Appearance:	NA
Mol. Weight:	270.21
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	2-Cyano-3-hydroxy-N-[3-(trifluoromethyl)phenyl]-2-butenamide is a derivative of Leflunomide which is an immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therapeutically as a antirheumatic (Merck Index). This compound is suitable for dihydroorotate dehydrogenase (DHODH) related research.