4-Hydroxydebrisoquine

In House Impurity

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Catalogue number:	PA 04 2781000
Chemical name:	4-Hydroxydebrisoquine
CAS Number:	59333-79-8
Category:	impurities,metabolites,pharmaceutical standards,intermediates,Fine Chemicals
Synonyms:	2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-4-hydroxy; 4-Hydroxy-3,4-dihydroisoquinoline-2(1H)-carboximidamide;
Molecular form:	C₁₀H₁₃N₃O
Appearance:	NA
Mol. Weight:	191.23
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	An adrenergic neuron-blocking drug similar in effects to guanethidine. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.