Aloisine A RP107

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Catalogue number:	PA 27 0016988
Chemical name:	Aloisine A RP107
CAS Number:	496864-16-5
Category:	miscellaneous compounds
Synonyms:	4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol;
Molecular form:	C₁₆H₁₇N₃O
Appearance:	Light Orangish Yellow solid
Mol. Weight:	267.33
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks: IC50 =150nM, 120 nM, 400 nM and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25, respectively). Also inhibits the activity of clycogen synthase kinase-3 (GSK-3,:(IC50 =500 nM and 1.5 uM for GSK-3a, GSK-3ß, respectively), and c-Jun N-terminal kinase (JNK: IC50 approx. 3-10uM).