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Catalogue number: PA 73 35000
Chemical name: Tandutinib

CAS Number:

387867-13-2

Category: impurities,metabolites,pharmaceutical standards,intermediates,Fine Chemicals
Synonyms:

4-[6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-1-piperazinecarboxamide; [4-[6-Methoxy-7-(3-piperidylpropoxy)quinazolin-4-yl]piperazinyl]-N-[4-(methylethoxy)phenyl]carboxamide; 1-Piperazinecarboxamide, 4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-;

Molecular form: C31H42N6O4
Appearance: White to Off-White Solid
Mol. Weight: 562.72
Storage: 2-8°C Refrigerator
Shipping Conditions: Ambient
Applications: An oral, small-molecule inhibitor of FLT3 for the treatment of AML (acute myelogenous leukemia) and other cancer indications. The drug exhibited limited activity as a single agent in phase I and II clinical trials in patients with AML and myelodysplastic syndrome, but displayed promising antileukemic activity (90% complete remissions) in a phase I/II trial in patients with newly diagnosed AML when administered in combination with cytarabine and daunorubicin.

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