Name: 1-Demethylcolchicine
Brand: Pharmaffliates
Rating: 4.00 (5 reviews)

Catalogue number:	PA 03 0741011
Chemical name:	1-Demethylcolchicine
CAS Number:	3464-68-4
Category:	impurities,metabolites,pharmaceutical standards,intermediates,Fine Chemicals
Synonyms:	(S)-N-(1-Hydroxy-2,3,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide; Acetamide, N-[(7S)-5,6,7,9-tetrahydro-1-hydroxy-2,3,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]; Acetamide, N-(5,6,7,9-tetrahydro-1-hydroxy-2,3,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S); Benzo[a]heptalene, acetamide deriv; Colchicine, 1-demethyl; N-[(7S)-5,6,7,9-Tetrahydro-1-hydroxy-2,3,10-trimethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide; (-)-1-Demethylcolchicine; Colchicine, demethyl-; O1-Demethylcolchicine;
Molecular form:	C₂₁H₂₃NO₆
Appearance:	NA
Mol. Weight:	385.42
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	1-Demethylcolchicine is a derivative of Colchicine an antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

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