4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

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Catalogue number:	PA 27 0016990
Chemical name:	4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
CAS Number:	327036-89-5
Category:	miscellaneous compounds
Synonyms:	4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione;
Molecular form:	C₁₀H₁₀N₂O₂S
Appearance:	White Solid
Mol. Weight:	222.26
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	Glycogen Synthase Kinase-3ß is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. TDZD-8 is a thiadiazolidinone (TDZD) analogue that acts as a highly selective, non-ATP competitive inhibitor of GSK-3ß ( IC50 =2nM). Binds to the active site of GSK-3ß. Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50 >100nM).