Name: Genistein-2',6'-d2
Brand: Pharmaffliates
Rating: 4.00 (5 reviews)

Catalogue number:	PA STI 088195
Chemical name:	Genistein-2',6'-d2
CAS Number:	315204-48-9
Category:	enzyme inhibitors,stable isotopes,tyrosine kinase inhibitors
Synonyms:	5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d2; Baichanin A-d2; Bonistein-d2; 4',5,7-Trihydroxyisoflavone-d2; GeniVida-d2; Genisteol-d2; NSC 36586-d2; Prunetol-d2; Sophoricol-d2; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl-3,5-d2);
Molecular form:	C₁₅H₈D₂O₅
Appearance:	Pale Yellow Solid
Mol. Weight:	272.25
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol.

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Genistein-2',6'-d2

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