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Catalogue number: PA 27 0017303
Chemical name: SANT-1

CAS Number:

304909-07-7

Category: miscellaneous compounds
Synonyms:

(E)-N-(4-Benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine;

Molecular form: C23H27N5
Appearance: Off-White to Pale Yellow Solid
Mol. Weight: 373.5
Storage: 2-8°C Refrigerator
Shipping Conditions: Ambient
Applications: A potent antagonist of the sonic hedgehog (Shh) signaling pathway (IC50=20nm inShh-LIGHT2 assay an d in Ptch1-/- cells) that acts by binding to smoothened (Smo: KD=1.2 nM), a distant relative of G protein-coupled receptors. In contrast to cyclopamine, SNAT-1 inhibits the activities of both wild type and oncogenic Smo with equal potency (IC50=30nm in SmoA1-LIGHT2 assay).

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