Netupitant - API Standards

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Catalogue number:	PA 14 1320000
Chemical name:	Netupitant
CAS Number:	290297-26-6
Category:	impurities,metabolites,pharmaceutical standards,intermediates,Fine Chemicals
Synonyms:	2-[3,5-Bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]propanamide; 2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethyl-N-(6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)propanamide;
Molecular form:	C₃₀H₃₂F₆N₄O
Appearance:	White to Off-White Solid
Mol. Weight:	578.6
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant is a neurokinin 1 receptor antagonist. The combination drug is marketed by Eisai Inc. and Helsinn Therapeutics under the brand Akynzeo.