(1R,4R)-rel-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Hydrochloride

In House Impurity
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Catalogue number: PA 28 0911000
Chemical name: (1R,4R)-rel-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Hydrochloride

CAS Number:

267668-71-3

Category: impurities,metabolites,pharmaceutical standards,Fine Chemicals
Synonyms:

2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, hydrochloride (1:1), (1R,4R)-rel-; 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, monohydrochloride, (1R,4R)-rel-;

Molecular form: C14H19ClN6O
Appearance: NA
Mol. Weight: 322.8
Storage: 2-8°C Refrigerator
Shipping Conditions: Ambient
Applications: (1R,​4R)​-​rel-4-​[2-Amino-​6-​(cyclopropylamino)​-​9H-​purin-​9-​yl]​-​2-​cyclopentene-​1-​methanol Hydrochloride (Abacavir - In House Impurity) is an impurity of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

(1R,4R)-rel-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Hydrochloride

267668-71-3
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