2-((2-Chloroethyl)(2-ethoxyethyl)amino)-1,3,2-oxazaphosphinane 2-oxide

In House Impurity

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Catalogue number:	PA 03 0831004
Chemical name:	2-((2-Chloroethyl)(2-ethoxyethyl)amino)-1,3,2-oxazaphosphinane 2-oxide
CAS Number:	2387771-96-0
Category:	impurities,metabolites,pharmaceutical standards,intermediates,Fine Chemicals
Synonyms:	2H-1,3,2-Oxazaphosphorin-2-amine, N-(2-chloroethyl)-N-(2-ethoxyethyl)tetrahydro-, 2-oxide
Molecular form:	C₉H₂₀ClN₂O₃P
Appearance:	NA
Mol. Weight:	270.69
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	N-(2-Chloroethyl)-N-(2-ethoxyethyl)tetrahydro-2H-1,3,2-Oxazaphosphorin-2-amine 2-Oxide is an impurity of Cyclophosphamide), a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen.