Pyrazine-2-carbonyl Chloride

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Catalogue number: PAI 02 079001
Chemical name: Pyrazine-2-carbonyl Chloride

CAS Number:

19847-10-0
Category: intermediates
Synonyms:

2-Pyrazinecarbonyl chloride; Pyrazinecarbonyl chloride; Pyrazinoyl chloride; Pyrazine-2-carboxylic acid chloride; Pyrazinoic Acid Chloride;
Molecular form: C5H3ClN2O
Appearance: NA
Mol. Weight: 142.54
Storage: 2-8°C Refrigerator
Shipping Conditions: Ambient
Applications: 2-Pyrazinecarbonyl Chloride is an intermediate used in the synthesis of (S)-N-[1-(3-Hydroxy-3-methylbutanamido)-1-oxo-3-phenylpropan-2yl]pyrazine-2-carboxamide, which is an impurity of bortezomib, which is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.

Pyrazine-2-carbonyl Chloride

19847-10-0
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